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    PF3D7_0211400 beta-ketoacyl-ACP synthase III [ Plasmodium falciparum 3D7 ]

    Gene ID: 812702, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0211400
    Gene description
    beta-ketoacyl-ACP synthase III
    Locus tag
    PF3D7_0211400
    See related
    PlasmoDB:PF3D7_0211400; VEuPathDB:PF3D7_0211400
    Gene type
    protein coding
    RNA name
    beta-ketoacyl-ACP synthase III
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0211400 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_037280.1 (459072..461518, complement)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene ras-related protein Rab-5A Neighboring gene ubiquinol-cytochrome-c reductase complex assembly factor 1, putative Neighboring gene GAF domain-related protein, putative Neighboring gene UDP-N-acetylglucosamine transferase subunit ALG14, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deciphering apicoplast targeting signals--feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins. Zuegge J, et al. Gene, 2001 Dec 12. PMID 11738814
    2. Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum. Waters NC, et al. Mol Biochem Parasitol, 2002 Aug 28. PMID 12270624
    3. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Science, 1998 Nov 6. PMID 9804551
    4. Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. Boucher MJ, et al. PLoS Biol, 2018 Sep. PMID 30212465, Free PMC Article
    5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables beta-ketoacyl-acyl-carrier-protein synthase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicoplast HDA PubMed 
    located_in apicoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-ketoacyl-ACP synthase III
    XP_001349620.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      459072..461518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349584.1 → XP_001349620.1  beta-ketoacyl-ACP synthase III [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349620.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VFC7, A0A2I0BVH0, O77078, O96194, Q7KWI9, W4IPL6, W7FQU1
      Conserved Domains (1) summary
      cd00830
      Location:52 → 369
      KAS_III; Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl ...
    Nucleotide Protein
    Heading Accession and Version

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