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    PF3D7_0421300 erythrocyte membrane protein 1, PfEMP1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 4794163, updated on 14-Nov-2024

    Summary

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    Gene symbol
    PF3D7_0421300
    Gene description
    erythrocyte membrane protein 1, PfEMP1
    Locus tag
    PF3D7_0421300
    See related
    PlasmoDB:PF3D7_0421300; VEuPathDB:PF3D7_0421300
    Gene type
    protein coding
    RNA name
    erythrocyte membrane protein 1, PfEMP1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_0421300 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_004318.2 (969031..976591, complement)

    Chromosome 4 - NC_004318.2Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein 1, PfEMP1 Neighboring gene rifin Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004318.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antigenic variation in Plasmodium falciparum. Scherf A, et al. Annu Rev Microbiol, 2008. PMID 18785843
    2. Variant antigens of Plasmodium falciparum encoded by the var multigenic family are multifunctional macromolecules. Nogueira PA, et al. Res Microbiol, 2001 Mar. PMID 11316367
    3. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Rowe JA, et al. Nature, 1997 Jul 17. PMID 9230440
    4. Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion. Craig A, et al. Mol Biochem Parasitol, 2001 Jul. PMID 11420100
    5. A recombinant peptide based on PfEMP-1 blocks and reverses adhesion of malaria-infected red blood cells to CD36 under flow. Cooke BM, et al. Mol Microbiol, 1998 Oct. PMID 9786187

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables cell adhesion molecule binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adhesion of symbiont to microvasculature TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within antigenic variation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont-mediated perturbation of host erythrocyte aggregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in host cell plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in infected host cell surface knob TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    erythrocyte membrane protein 1, PfEMP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004318.2 Reference assembly

      Range
      969031..976591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351481.1 → XP_001351517.1  erythrocyte membrane protein 1, PfEMP1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351517.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S9VR11, Q8IFQ2
      Conserved Domains (5) summary
      PTZ00176
      Location:1 → 454
      PTZ00176; erythrocyte membrane protein 1 (PfEMP1); Provisional
      pfam03011
      Location:1485 → 1626
      PFEMP; PFEMP DBL domain
      pfam15445
      Location:1749 → 2193
      ATS; acidic terminal segments, variant surface antigen of PfEMP1
      pfam05424
      Location:124 → 317
      Duffy_binding; Duffy binding domain
      pfam18562
      Location:1422 → 1470
      CIDR1_gamma; Cysteine-Rich Interdomain Region 1 gamma
    Nucleotide Protein
    Heading Accession and Version

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