U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PF3D7_0510500 topoisomerase I [ Plasmodium falciparum 3D7 ]

    Gene ID: 812833, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PF3D7_0510500
    Gene description
    topoisomerase I
    Locus tag
    PF3D7_0510500
    See related
    PlasmoDB:PF3D7_0510500; VEuPathDB:PF3D7_0510500
    Gene type
    protein coding
    RNA name
    topoisomerase I
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PF3D7_0510500 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_004326.2 (445983..448502, complement)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene stripes inner membrane complex protein, putative Neighboring gene PDCD2 domain-containing protein, putative Neighboring gene tRNA-Leu Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum. Cortopassi WA, et al. PLoS One, 2014. PMID 24651068, Free PMC Article
    2. Mapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leads. Jensen K, et al. Mol Biosyst, 2012 Jun. PMID 22446744
    3. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Oehring SC, et al. Genome Biol, 2012 Nov 26. PMID 23181666, Free PMC Article
    4. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    topoisomerase I
    XP_001351663.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      445983..448502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351627.1 → XP_001351663.1  topoisomerase I [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351663.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VBZ5, A0A024VH83, A0A024WBA0, A0A024WUM1, A0A024XCW0, A0A0L1IEH6, A0A0L7KJC9, A0A0L7M6N6, Q26024, Q8I3Z9, W4ILF3, W4IW20, W7FCQ9, W7FN72, W7K2W7, W7KKW1
      Conserved Domains (2) summary
      smart00435
      Location:308 → 812
      TOPEUc; DNA Topoisomerase I (eukaryota)
      cd03490
      Location:155 → 381
      Topoisomer_IB_N_1; A subgroup of the N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB. Topo IB proteins include the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous