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    PF3D7_0524000 karyopherin beta [ Plasmodium falciparum 3D7 ]

    Gene ID: 813054, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0524000
    Gene description
    karyopherin beta
    Locus tag
    PF3D7_0524000
    See related
    PlasmoDB:PF3D7_0524000; VEuPathDB:PF3D7_0524000
    Gene type
    protein coding
    RNA name
    karyopherin beta
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0524000 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_004326.2 (998753..1002124)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene divalent metal transporter, putative Neighboring gene MerC domain-containing protein, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium membrane protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of Plasmodium falciparum homologs of nuclear import factors, karyopherin alpha and karyopherin beta. Mohmmed A, et al. Mol Biochem Parasitol, 2003 Apr 3. PMID 12672529
    2. Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodium falciparum blood-stage development. Baumgarten S, et al. Nat Microbiol, 2019 Dec. PMID 31384004, Free PMC Article
    3. Food vacuole proteome of the malarial parasite Plasmodium falciparum. Lamarque M, et al. Proteomics Clin Appl, 2008 Sep. PMID 21136929
    4. Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite. Sinha A, et al. mBio, 2021 Apr 27. PMID 33906926, Free PMC Article
    5. Identification of Plasmodium falciparum nuclear proteins by mass spectrometry and proposed protein annotation. Briquet S, et al. PLoS One, 2018. PMID 30379851, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within NLS-bearing protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex HDA PubMed 
    located_in food vacuole HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    karyopherin beta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      998753..1002124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351760.1 → XP_001351796.1  karyopherin beta [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351796.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VA72, A0A024WBG5, A0A024WVK7, A0A024XDK1, A0A0L1ICV0, A0A0L7KEA9, Q7KAU3, Q8I3M5, W4ILN8, W4IVM8, W7FHA1, W7GB28, W7JT88, W7KKK0
      Conserved Domains (4) summary
      COG5215
      Location:511 → 687
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:390 → 421
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:433 → 541
      HEAT_2; HEAT repeats
      pfam18808
      Location:294 → 374
      Importin_rep_4; Importin repeat
    Nucleotide Protein
    Heading Accession and Version

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