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    PF3D7_1229100 multidrug resistance-associated protein 2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 811334, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1229100
    Gene description
    multidrug resistance-associated protein 2
    Locus tag
    PF3D7_1229100
    See related
    PlasmoDB:PF3D7_1229100; VEuPathDB:PF3D7_1229100
    Gene type
    protein coding
    RNA name
    multidrug resistance-associated protein 2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1229100 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Sequence:
    Chromosome: 12; NC_037284.1 (1192888..1199214, complement)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene ncRNA Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony. Goswami D, et al. iScience, 2022 May 20. PMID 35521513, Free PMC Article
    2. Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs. Mok S, et al. Mol Microbiol, 2014 Mar. PMID 24372851, Free PMC Article
    3. Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane. Kavishe RA, et al. Malar J, 2009 Aug 28. PMID 19715599, Free PMC Article
    4. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. Krogh A, et al. J Mol Biol, 2001 Jan 19. PMID 11152613
    5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within schizogony IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug resistance-associated protein 2
    XP_001350688.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      1192888..1199214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350652.1 → XP_001350688.1  multidrug resistance-associated protein 2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350688.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I0BYJ5, D5L5S7, Q8I5C7
      Conserved Domains (3) summary
      COG1132
      Location:1388 → 2084
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl38913
      Location:386 → 582
      ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
      cl38936
      Location:758 → 903
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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