U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PF3D7_1247400 peptidyl-prolyl cis-trans isomerase FKBP35 [ Plasmodium falciparum 3D7 ]

    Gene ID: 811507, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PF3D7_1247400
    Gene description
    peptidyl-prolyl cis-trans isomerase FKBP35
    Locus tag
    PF3D7_1247400
    See related
    PlasmoDB:PF3D7_1247400; VEuPathDB:PF3D7_1247400
    Gene type
    protein coding
    RNA name
    peptidyl-prolyl cis-trans isomerase FKBP35
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PF3D7_1247400 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Sequence:
    Chromosome: 12; NC_037284.1 (1955124..1956038, complement)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene hypothetical protein Neighboring gene serine/threonine protein kinase, putative Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. Atack TC, et al. ACS Med Chem Lett, 2020 Nov 12. PMID 33209191, Free PMC Article
    2. Expression, purification, and molecular characterization of Plasmodium falciparum FK506-binding protein 35 (PfFKBP35). Yoon HR, et al. Protein Expr Purif, 2007 May. PMID 17289400
    3. A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities. Monaghan P, et al. Mol Biochem Parasitol, 2005 Feb. PMID 15664653
    4. The FK506-binding protein of the malaria parasite, Plasmodium falciparum, is a FK506-sensitive chaperone with FK506-independent calcineurin-inhibitory activity. Kumar R, et al. Mol Biochem Parasitol, 2005 Jun. PMID 15850699
    5. Identification of Plasmodium falciparum nuclear proteins by mass spectrometry and proposed protein annotation. Briquet S, et al. PLoS One, 2018. PMID 30379851, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterisation of the first member of the FKBP family identified in Plasmodium falciparum
      Title: A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables FK506 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP35
    XP_001350859.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      1955124..1956038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350823.1 → XP_001350859.1  peptidyl-prolyl cis-trans isomerase FKBP35 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350859.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8I4V8
      UniProtKB/TrEMBL
      A0A024V445, A0A024VEX6, A0A024W3L4, A0A024WMR5, A0A024X4E7, A0A0L1IEI2, A0A0L7KF76, W4IE55, W4J3A4, W7F4A3, W7G1A9, W7JR25, W7JUC3
      Conserved Domains (3) summary
      TIGR00990
      Location:131 → 284
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:148 → 172
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:34 → 123
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous