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    CSM4 Csm4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855901, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSM4
    Official Full Name
    Csm4p
    Primary source
    SGD:S000006121
    Locus tag
    YPL200W
    See related
    AllianceGenome:SGD:S000006121; FungiDB:YPL200W; VEuPathDB:YPL200W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cytoskeleton-nuclear membrane anchor activity. Involved in homologous chromosome pairing at meiosis; meiotic telomere clustering; and regulation of reciprocal meiotic recombination. Located in chromosome, telomeric region; endoplasmic reticulum membrane; and nuclear outer membrane. Part of meiotic nuclear membrane microtubule tethering complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CSM4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (171484..171954)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Aft2p Neighboring gene Yig1p Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L7B Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sustained and rapid chromosome movements are critical for chromosome pairing and meiotic progression in budding yeast. Sonntag Brown M, et al. Genetics, 2011 May. PMID 21339478, Free PMC Article
    2. A selfish DNA element engages a meiosis-specific motor and telomeres for germ-line propagation. Sau S, et al. J Cell Biol, 2014 Jun 9. PMID 24914236, Free PMC Article
    3. Telomere-led meiotic chromosome movements: recent update in structure and function. Lee CY, et al. Nucleus, 2020 Jan 1. PMID 32412326, Free PMC Article
    4. Evidence for a dual role of actin in regulating chromosome organization and dynamics in yeast. Spichal M, et al. J Cell Sci, 2016 Feb 15. PMID 26763908
    5. The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae. Komachi K, et al. Genetics, 2022 May 5. PMID 35302609, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
      Title: Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
    2. Csm4 is required for several distinct steps during meiotic recombination.
      Title: Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination.
    3. Unlike Ndj1, Csm4 is not required for meiosis-specific telomere association.
      Title: Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytoskeleton-nuclear membrane anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic telomere clustering IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic telomere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Csm4p
    NP_015124.1
    • Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      171484..171954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184014.1 → NP_015124.1  TPA: Csm4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015124.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3G9, Q08955
      UniProtKB/TrEMBL
      A6ZW54, B3LKM9, C7GN28, G2WNY4, N1NW99
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08955.1

    Gene LinkOut

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