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    MBF1 multiprotein-bridging factor 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854474, updated on 17-Dec-2024

    Summary

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    Official Symbol
    MBF1
    Official Full Name
    multiprotein-bridging factor 1
    Primary source
    SGD:S000007253
    Locus tag
    YOR298C-A
    See related
    AllianceGenome:SGD:S000007253; FungiDB:YOR298C-A; VEuPathDB:YOR298C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SUF13
    Summary
    Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in mitochondrion. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MBF1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (877230..877685, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tim18p Neighboring gene Mum3p Neighboring gene exomer complex subunit Neighboring gene Rax1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The potato transcriptional co-activator StMBF1 is up-regulated in response to oxidative stress and interacts with the TATA-box binding protein. Arce DP, et al. J Biochem Mol Biol, 2006 Jul 31. PMID 16889677
    2. Primary structure of wild-type and mutant alleles of the PET494 gene of Saccharomyces cerevisiae. Costanzo MC, et al. Mol Gen Genet, 1986 Feb. PMID 3010052
    3. Frameshift suppression in Saccharomyces cerevisiae. V. Isolation and genetic properties of nongroup-specific suppressors. Culbertson MR, et al. Genetics, 1982 Nov. PMID 6757053, Free PMC Article
    4. Multiprotein-bridging factor 1 regulates vegetative growth, osmotic stress, and virulence in Magnaporthe oryzae. Fan G, et al. Curr Genet, 2017 May. PMID 27485943
    5. Compensatory change of interacting amino acids in the coevolution of transcriptional coactivator MBF1 and TATA-box-binding protein. Liu QX, et al. Mol Biol Evol, 2007 Jul. PMID 17440176

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mbf1 and Rps3 cooperate to maintain the reading frame of stalled ribosomes, while Asc1 also mediates distinct events that result in recruitment of the ribosome quality control complex and mRNA decay.
      Title: Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting.
    2. evidence for compensatory changes of transcription coactivator and its interacting target, presenting the report that transcription coactivator may have undergone coevolution with TBP
      Title: Compensatory change of interacting amino acids in the coevolution of transcriptional coactivator MBF1 and TATA-box-binding protein.
    3. A negative feedback loop involving Nrm1 bound to MBF leads to transcriptional repression as cells exit G1 phase.
      Title: Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multiprotein-bridging factor 1
    NP_014942.4
    • Core integrated stress response (ISR) factor; optimizes ribosome collision-mediated Gcn2 activation and the downstream Gcn4-mediated transcriptional response; required for optimal stress-induced eIF2alpha (Sui2p) phosphorylation and downstream de-repression of GCN4 translation; Mbf1p is recruited to collided disomes and trisomes during the ISR; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress; homologous to human EDF1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      877230..877685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184346.3 → NP_014942.4  TPA: multiprotein-bridging factor 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014942.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Z8, O14467, Q7LGJ8, Q86ZS7
      UniProtKB/TrEMBL
      A6ZPD4, B3LJW3, C7GNW2, C8ZH49, G2WNG5, N1P3R3
      Conserved Domains (2) summary
      COG1813
      Location:46 → 150
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:3 → 75
      MBF1; Multiprotein bridging factor 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14467.2

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