UAF30 Uaf30p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UAF30
Official Full Name: Uaf30p
Primary source: SGD:S000005821
Locus tag: YOR295W
See related: AllianceGenome:SGD:S000005821; FungiDB:YOR295W; VEuPathDB:YOR295W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables RNA polymerase I cis-regulatory region sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Involved in chromatin organization and nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase I upstream activating factor complex. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA polymerase I cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase I general transcription initiation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleolar large rRNA transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase I promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase I upstream activating factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I upstream activating factor complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014938.3

Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain