RGA1 GTPase-activating protein RGA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RGA1
Official Full Name: GTPase-activating protein RGA1
Primary source: SGD:S000005653
Locus tag: YOR127W
See related: AllianceGenome:SGD:S000005653; FungiDB:YOR127W; VEuPathDB:YOR127W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DBM1; THE1
Summary: Enables GTPase activator activity. Involved in several processes, including axial cellular bud site selection; budding cell apical bud growth; and cytoskeleton organization. Located in cellular birth scar; cellular bud neck split septin rings; and cellular bud scar. Orthologous to several human genes including ARHGAP12 (Rho GTPase activating protein 12) and ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RGA1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (561170..564193)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdc42-Specific GTPase-Activating Protein Rga1 Squelches Crosstalk between the High-Osmolarity Glycerol (HOG) and Mating Pheromone Response MAPK Pathways.
Title: Cdc42-Specific GTPase-Activating Protein Rga1 Squelches Crosstalk between the High-Osmolarity Glycerol (HOG) and Mating Pheromone Response MAPK Pathways.
Biphasic mathematical model of Cdc42 polarization predicts that premature delocalization of Rga1 leads to more frequent Cdc42 repolarization within the division site when the first temporal step in G1 is assumed to last longer.
Title: Fine-tuning the orientation of the polarity axis by Rga1, a Cdc42 GTPase-activating protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axial cellular bud site selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in budding cell apical bud growth	IPI Inferred from Physical Interaction more info	PubMed
involved_in budding cell isotropic bud growth	IPI Inferred from Physical Interaction more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in invasive growth in response to glucose limitation	IPI Inferred from Physical Interaction more info	PubMed
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of pseudohyphal growth	IPI Inferred from Physical Interaction more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in septin ring organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell tip	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular birth scar	IDA Inferred from Direct Assay more info	PubMed
is_active_in cellular bud	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck split septin rings	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud scar	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTPase-activating protein RGA1

NP_014770.1

GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

561170..564193

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183546.1 → NP_014770.1 TPA: GTPase-activating protein RGA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014770.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2I5, P39083, P39934

UniProtKB/TrEMBL

A6ZNX4, C7GML2, N1NWM0

Conserved Domains (4) summary

cd09394
Location:13 → 67

LIM1_Rga; The first LIM domain of Rga GTPase-Activating Proteins

cd09395
Location:70 → 123

LIM2_Rga; The second LIM domain of Rga GTPase-Activating Proteins

smart00324
Location:803 → 1002

RhoGAP; GTPase-activator protein for Rho-like GTPases

COG1196
Location:569 → 673

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]