SRT1 ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SRT1
Official Full Name: ditrans,polycis-polyprenyl diphosphate synthase
Primary source: SGD:S000004707
Locus tag: YMR101C
See related: AllianceGenome:SGD:S000004707; FungiDB:YMR101C; VEuPathDB:YMR101C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dehydrodolichyl diphosphate synthase activity. Involved in dolichol biosynthetic process and protein glycosylation. Located in lipid droplet. Part of dehydrodolichyl diphosphate synthase complex. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Orthologous to human DHDDS (dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SRT1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (468445..469476, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synthesis of chitin by Chs3, the chitin synthase responsible for chitosan layer formation, is dependent on the cis-prenyltransferase activity of Srt1, indicating that polyprenols are necessary to coordinate assembly of the spore wall layers.
Title: Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae.
Mutants of S. cerevisiae showed a very high activity level of SRT1.
Title: Protein glycosylation in pmt mutants of Saccharomyces cerevisiae. Influence of heterologously expressed cellobiohydrolase II of Trichoderma reesei and elevated levels of GDP-mannose and cis-prenyltransferase activity.
the activities of two yeast cis prenyltransferases Rer2p and Srt1p and polyprenol reductase are not co-regulated and reductase may be the rate-limiting enzyme in dolichol synthesis if the amount of polyisoprenoids synthesized exceeds a certain level.
Title: Interplay between the cis-prenyltransferases and polyprenol reductase in the yeast Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to dehydrodolichyl diphosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to dehydrodolichyl diphosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydrodolichyl diphosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydrodolichyl diphosphate synthase activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dolichol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dolichol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of dehydrodolichyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dehydrodolichyl diphosphate synthase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	HDA more info	PubMed
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ditrans,polycis-polyprenyl diphosphate synthase

NP_013819.1

EC 2.5.1.87

Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

468445..469476 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182601.1 → NP_013819.1 TPA: ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013819.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZS4, Q03175

UniProtKB/TrEMBL

A6ZMF8, B3LLZ2, C7GVD8, C8ZEV3, G2WKE9

Conserved Domains (1) summary

TIGR00055
Location:68 → 292

uppS; undecaprenyl diphosphate synthase