NGK1 hexokinase [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: NGK1
Official Full Name: hexokinase
Primary source: SGD:S000004438
Locus tag: YLR446W
See related: AllianceGenome:SGD:S000004438; FungiDB:YLR446W; VEuPathDB:YLR446W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables N-acetylglucosamine kinase activity. Involved in UDP-N-acetylglucosamine biosynthetic process and chitin biosynthetic process. Predicted to be active in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See NGK1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (1025214..1026515)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ngk1 kinase-mediated N-acetylglucosamine metabolism promotes UDP-GlcNAc biosynthesis in Saccharomyces cerevisiae.
Title: Ngk1 kinase-mediated N-acetylglucosamine metabolism promotes UDP-GlcNAc biosynthesis in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables N-acetylglucosamine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylglucosamine kinase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylglucosamine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carbohydrate kinase activity	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hexokinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables mannokinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in UDP-N-acetylglucosamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in chitin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mannose metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: hexokinase

NP_013551.1

EC 2.7.1.59

N-acetylglucosamine (GlcNAc) kinase; requires a divalent cation and a broad range of NTPs as phosphoryl donor to generate GlcNAc-6-phosphate, a substrate for glycan biosynthesis; promotes UDP-GlcNAc biosynthesis a precursor for chitin production; phylogenically distinct from known GlcNAc kinases and hexokinases; transcript is upregulated during sporulation and the unfolded protein response; contains a hexokinase-like ATPase domain; non-essential gene

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

1025214..1026515

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182334.1 → NP_013551.1 TPA: hexokinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013551.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ80, Q06204, Q6B2U1

UniProtKB/TrEMBL

A7A1W5, N1P1Z2

Conserved Domains (1) summary

COG5026
Location:1 → 433

COG5026; Hexokinase [Carbohydrate transport and metabolism]