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    MMR1 Mmr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MMR1
    Official Full Name
    Mmr1p
    Primary source
    SGD:S000004180
    Locus tag
    YLR190W
    See related
    AllianceGenome:SGD:S000004180; FungiDB:YLR190W; VEuPathDB:YLR190W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phospholipid binding activity. Involved in mitochondrion inheritance. Acts upstream of or within intracellular distribution of mitochondria. Located in several cellular components, including cortical endoplasmic reticulum; incipient cellular bud site; and mitochondrial outer membrane. Is active in cellular bud. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MMR1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (535214..536689)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette permease MDL1 Neighboring gene sterol 3-beta-glucosyltransferase Neighboring gene peroxin PEX13 Neighboring gene translation initiation factor eIF3 core subunit j

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. McFaline-Figueroa JR, et al. Aging Cell, 2011 Oct. PMID 21726403, Free PMC Article
    2. [Phosphorylation of YLR190w by PAP1 PHO85 kinase complex]. Shi XZ, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Mar. PMID 12006994
    3. Selective retention of dysfunctional mitochondria during asymmetric cell division in yeast. Chelius X, et al. PLoS Biol, 2023 Sep. PMID 37721958, Free PMC Article
    4. A role for cell polarity in lifespan and mitochondrial quality control in the budding yeast Saccharomyces cerevisiae. Yang EJ, et al. iScience, 2022 Mar 18. PMID 35281729, Free PMC Article
    5. Direct membrane binding and self-interaction contribute to Mmr1 function in mitochondrial inheritance. Chen W, et al. Mol Biol Cell, 2018 Sep 15. PMID 30044712, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae.
      Title: Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae.
    2. Mmr1p contributes to mitochondrial inheritance as a mediator of anchorage of mitochondria to cER sheets in the yeast bud tip.
      Title: Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular distribution of mitochondria IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mmr1p
    NP_013291.1
    • Phospholipid binding protein; interacts with mitochondria and with Myo2p, functioning as an adaptor that recruits Myo2p and facilitates actin-based transport of mitochondria to the bud; mediates mitochondria anchorage at the bud tip; phosphorylated protein that localizes to the mitochondrial outer membrane; mRNA is targeted to the bud via the transport system involving She2p; member of the DSL1 family of tethering proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      535214..536689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182077.1 → NP_013291.1  TPA: Mmr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013291.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYJ3, Q06324
      UniProtKB/TrEMBL
      B3RH81, C7GIX7, C8ZDF8, N1NYC9
      Conserved Domains (1) summary
      pfam08505
      Location:60 → 281
      MMR1; Mitochondrial Myo2 receptor-related protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06324.1

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