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    TOS4 Tos4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOS4
    Official Full Name
    Tos4p
    Primary source
    SGD:S000004173
    Locus tag
    YLR183C
    See related
    AllianceGenome:SGD:S000004173; FungiDB:YLR183C; VEuPathDB:YLR183C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Involved in DNA damage response and regulation of gene expression. Located in chromatin and nucleus. Part of Rpd3L-Expanded complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOS4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (520543..522012, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Vta1p Neighboring gene transcriptional regulator SWI6 Neighboring gene ribosomal 60S subunit protein L37A Neighboring gene 18S rRNA pseudouridine methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression homeostasis during DNA replication. Voichek Y, et al. Science, 2016 Mar 4. PMID 26941319
    2. Tos4 mediates gene expression homeostasis through interaction with HDAC complexes independently of H3K56 acetylation. Cooke SL, et al. J Biol Chem, 2021 Jan-Jun. PMID 33713703, Free PMC Article
    3. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Tu BP, et al. Science, 2005 Nov 18. PMID 16254148
    4. Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes. Bastos de Oliveira FM, et al. EMBO J, 2012 Apr 4. PMID 22333912, Free PMC Article
    5. High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae. Bean JM, et al. Genetics, 2005 Sep. PMID 15965243, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex HDA PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tos4p
    NP_013284.1
    • Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      520543..522012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182070.1 → NP_013284.1  TPA: Tos4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013284.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYI7, Q06266
      UniProtKB/TrEMBL
      A7A174, C7GIX2, G2WJ16, N1NZD4
      Conserved Domains (1) summary
      cd00060
      Location:113 → 172
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06266.1

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