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    RIC1 Ric1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIC1
    Official Full Name
    Ric1p
    Primary source
    SGD:S000004029
    Locus tag
    YLR039C
    See related
    AllianceGenome:SGD:S000004029; FungiDB:YLR039C; VEuPathDB:YLR039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in intracellular protein transport and retrograde transport, endosome to Golgi. Located in Golgi membrane and cis-Golgi network. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RIC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (225426..228596, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene seripauperin PAU23 Neighboring gene cytochrome c oxidase subunit VIb Neighboring gene Afb1p Neighboring gene Nfg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RIC1, a novel gene required for ribosome synthesis in Saccharomyces cerevisiae. Mizuta K, et al. Gene, 1997 Mar 18. PMID 9099877
    2. Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors. Suástegui M, et al. Metab Eng, 2017 Jul. PMID 28625755
    3. Characterization of MYR1, a dosage suppressor of YPT6 and RIC1 deficient mutants. Georgiev A, et al. Curr Genet, 2008 Apr. PMID 18327588
    4. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. Siniossoglou S, et al. EMBO J, 2000 Sep 15. PMID 10990452, Free PMC Article
    5. Decreased aluminium tolerance in the growth of Saccharomyces cerevisiae with SSO2 gene disruption. Yamamoto T, et al. Biometals, 2018 Apr. PMID 29383568

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ric1p
    NP_013140.1
    • Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      225426..228596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181926.1 → NP_013140.1  TPA: Ric1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013140.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY42, P40395
      UniProtKB/TrEMBL
      B3LT11, C7GU50, C8ZD11
      Conserved Domains (1) summary
      pfam07064
      Location:820 → 1045
      RIC1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40395.1

    Gene LinkOut

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