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    SPO13 Spo13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPO13
    Official Full Name
    Spo13p
    Primary source
    SGD:S000001056
    Locus tag
    YHR014W
    See related
    AllianceGenome:SGD:S000001056; FungiDB:YHR014W; VEuPathDB:YHR014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in meiotic sister chromatid cohesion; positive regulation of sister chromatid cohesion; and protein localization to chromosome, centromeric region. Located in condensed chromosome, centromeric region; meiotic spindle; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPO13 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (132047..132922)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene retromer subunit VPS29 Neighboring gene peptide alpha-N-acetyltransferase complex A subunit ARD1 Neighboring gene tRNA-Ser Neighboring gene tRNA-Gln

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. Sullivan M, et al. J Biol Chem, 2007 Jul 6. PMID 17493939
    2. Early meiotic transcripts are highly unstable in Saccharomyces cerevisiae. Surosky RT, et al. Mol Cell Biol, 1992 Sep. PMID 1508196, Free PMC Article
    3. Nucleotide sequence and promoter analysis of SPO13, a meiosis-specific gene of Saccharomyces cerevisiae. Buckingham LE, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2123556, Free PMC Article
    4. Meiotic chromosomal recombination defect in sake yeasts. Shimoi H, et al. J Biosci Bioeng, 2019 Feb. PMID 30181034
    5. Developmental regulation of SPO13, a gene required for separation of homologous chromosomes at meiosis I. Wang HT, et al. Mol Cell Biol, 1987 Apr. PMID 3299047, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spo13/MEIKIN ensures a Two-Division meiosis by preventing the activation of APC/C[Ama1] at meiosis I.
      Title: Spo13/MEIKIN ensures a Two-Division meiosis by preventing the activation of APC/C(Ama1) at meiosis I.
    2. The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
      Title: The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
    3. results outline complex interactions, in cis and in trans, between genes encoding PAF1 and ESCRT-II complex components that affect telomere function and cell viability in yeast
      Title: An interplay between Shugoshin and Spo13 for centromeric cohesin protection and sister kinetochore mono-orientation during meiosis I in Saccharomyces cerevisiae.
    4. Dbf4-dependent Cdc7 kinase (DDK) regulates monopolin localization together with the polo-kinase Cdc5 bound to Spo13, probably through phosphorylation of the monopolin subunit Lrs4
      Title: Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I.
    5. Spo13 destruction in anaphase I is not essential for meiosis.
      Title: A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I.
    6. Spo13 is required to prevent sister kinetochore biorientation by facilitating the recruitment of the monopolin complex to kinetochores during meiosis 1.
      Title: Spo13 facilitates monopolin recruitment to kinetochores and regulates maintenance of centromeric cohesion during yeast meiosis.
    7. Spo13 has the ability to regulate both the stepwise loss of sister chromatid cohesion and kinetochore coorientation, two essential features of chromosome segregation during meiosis 1.
      Title: Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spo13p
    NP_011878.1
    • Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; promotes phosphorylation of Cdc5p substrates in MI and impacts Hrr25p function in MII; substrate of the anaphase-promoting complex (APC) that is degraded during anaphase I; expressed solely in meiotic cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      132047..132922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179144.1 → NP_011878.1  TPA: Spo13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011878.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKV9, P23624
      UniProtKB/TrEMBL
      A6ZSR8, G2WF82, N1P537
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23624.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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