ARO10 phenylpyruvate decarboxylase ARO10 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ARO10
Official Full Name: phenylpyruvate decarboxylase ARO10
Primary source: SGD:S000002788
Locus tag: YDR380W
See related: AllianceGenome:SGD:S000002788; FungiDB:YDR380W; VEuPathDB:YDR380W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phenylpyruvate decarboxylase activity. Involved in carboxylic acid catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ARO10 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1234218..1236125)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Known aromatic amino acid permeases play an insignificant role in the heat-induced expression of ARO9 and ARO10, suggesting that an increase in plasma membrane fluidity might be responsible for the influx of aromatic amino acids during heat shock stress.
Title: Activation of Aro80 transcription factor by heat-induced aromatic amino acid influx in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-hydroxyphenylpyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-2-oxoacid decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables indolepyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phenylpyruvate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables phenylpyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in L-leucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-phenylalanine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amino acid catabolic process via Ehrlich pathway	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branched-chain amino acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid catabolic process to alcohol via Ehrlich pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in methionine catabolic process to 3-methylthiopropanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tyrosine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phenylpyruvate decarboxylase ARO10

NP_010668.3

EC 4.1.1.43

EC 4.1.1.72

EC 4.1.1.74

EC 4.1.1.80

Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1234218..1236125

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180688.3 → NP_010668.3 TPA: phenylpyruvate decarboxylase ARO10 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010668.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT13, Q06408

UniProtKB/TrEMBL

A0A166MTJ5, A6ZYY0, C7GMF5, C8Z5U4, M4WIW8, M4X0E1, N1P7B5

Conserved Domains (1) summary

COG3961
Location:22 → 635

PDC1; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]