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    TVP23 Tvp23p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TVP23
    Official Full Name
    Tvp23p
    Primary source
    SGD:S000002491
    Locus tag
    YDR084C
    See related
    AllianceGenome:SGD:S000002491; FungiDB:YDR084C; VEuPathDB:YDR084C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in vesicle-mediated transport. Located in Golgi membrane. Orthologous to several human genes including TVP23C-CDRT4 (TVP23C-CDRT4 readthrough); TVP23A (trans-golgi network vesicle protein 23 homolog A); and TVP23B (trans-golgi network vesicle protein 23 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TVP23 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (613405..614004, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Stn1p Neighboring gene 25S rRNA (adenine645-N1)-methyltransferase Neighboring gene Afr1p Neighboring gene translocon subunit SSS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi. Stein IS, et al. Biochem J, 2009 Apr 1. PMID 19076069
    2. Conserved Arabidopsis ECHIDNA protein mediates trans-Golgi-network trafficking and cell elongation. Gendre D, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21512130, Free PMC Article
    3. The phox homology (PX) domain protein interaction network in yeast. Vollert CS, et al. Mol Cell Proteomics, 2004 Nov. PMID 15263065
    4. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
    5. A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Millson SH, et al. Eukaryot Cell, 2005 May. PMID 15879519, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that Tvp23p performs a partially redundant function in retrograde transport from the early endosome to the late Golgi.
      Title: TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi.
    2. Tvp proteins collectively assist in the effective maintenance/function of the late Golgi/endosomal compartments.
      Title: Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tvp23p
    NP_010369.3
    • Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      613405..614004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180392.3 → NP_010369.3  TPA: Tvp23p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010369.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZY50, D6VS71, P38962
      UniProtKB/TrEMBL
      B3LGI7, B5VFY0, C8Z502, G2WAI9, N1P696
      Conserved Domains (1) summary
      pfam05832
      Location:15 → 156
      DUF846; Eukaryotic protein of unknown function (DUF846)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38962.1

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