SUL1 sulfate permease [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SUL1
Official Full Name: sulfate permease
Primary source: SGD:S000000498
Locus tag: YBR294W
See related: AllianceGenome:SGD:S000000498; FungiDB:YBR294W; VEuPathDB:YBR294W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SFP2
Summary: Enables sulfate transmembrane transporter activity. Involved in sulfate transmembrane transport. Located in plasma membrane. Orthologous to human SLC26A11 (solute carrier family 26 member 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SUL1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (789235..791814)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

while amplification of the SUL1 locus was detected in S. paradoxus and S. mikatae populations, S. uvarum cultures instead selected for amplification of the paralog, SUL2. We measured the relative fitness of strains bearing deletions and amplifications of both SUL genes from different species, confirming that, converse to S. cerevisiae, S. uvarum SUL2 contributes more to fitness in sulfate limitation than S. uvarum SUL1
Title: Differential paralog divergence modulates genome evolution across yeast species.
Yeast Sul1 and Sul2 are sulfate transceptors that signal to PKA in the absence of sulfate transport.
Title: Sul1 and Sul2 sulfate transceptors signal to protein kinase A upon exit of sulfur starvation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sulfate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: sulfate permease

NP_009853.3

High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

789235..791814

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178642.3 → NP_009853.3 TPA: sulfate permease [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009853.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQT8, P38359

UniProtKB/TrEMBL

A6ZLN1, B5VEN8, C7GMT9, G2W9U6, N1P7A9

Conserved Domains (1) summary

COG0659
Location:102 → 784

SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]