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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852244, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000000132
    Locus tag
    YBL036C
    See related
    AllianceGenome:SGD:S000000132; FungiDB:YBL036C; VEuPathDB:YBL036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyridoxal phosphate binding activity. Involved in vitamin B6 metabolic process. Predicted to be located in cytoplasm and nucleus. Used to study early-onset vitamin B6-dependent epilepsy 1. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 1. Orthologous to human PLPBP (pyridoxal phosphate binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (150447..151220, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL47 Neighboring gene Apl3p Neighboring gene DNA-directed DNA polymerase alpha subunit POL12 Neighboring gene Stu1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a yeast hypothetical protein selected by a structural genomics approach. Eswaramoorthy S, et al. Acta Crystallogr D Biol Crystallogr, 2003 Jan. PMID 12499548
    2. Maintenance of cellular vitamin B(6) levels and mitochondrial oxidative function depend on pyridoxal 5'-phosphate homeostasis protein. Ciapaite J, et al. J Biol Chem, 2023 Sep. PMID 37451483, Free PMC Article
    3. PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. Johnstone DL, et al. Brain, 2019 Mar 1. PMID 30668673, Free PMC Article
    4. Insight into the Antioxidant Effect of Fermented and Non-Fermented Spirulina Water and Ethanol Extracts at the Proteome Level Using a Yeast Cell Model. Masten Rutar J, et al. Antioxidants (Basel), 2021 Aug 27. PMID 34572998, Free PMC Article
    5. Global protein expression profiling of budding yeast in response to DNA damage. Lee MW, et al. Yeast, 2007 Mar. PMID 17351896

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vitamin B6 metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vitamin B6 metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_009517.1
    • Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      150447..151220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178276.1 → NP_009517.1  TPA: uncharacterized protein YBL036C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPW3, P38197, Q6B256
      UniProtKB/TrEMBL
      A6ZKR1, B3LNH4, B5VDU5, C7GNC6, C8Z3W1, G2W8X2, N1P7D9
      Conserved Domains (1) summary
      TIGR00044
      Location:1 → 248
      TIGR00044; pyridoxal phosphate enzyme, YggS family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38197.1

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