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    HTA2 histone H2A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HTA2
    Official Full Name
    histone H2A
    Primary source
    SGD:S000000099
    Locus tag
    YBL003C
    See related
    AllianceGenome:SGD:S000000099; FungiDB:YBL003C; VEuPathDB:YBL003C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    H2A2
    Summary
    Predicted to be a structural constituent of chromatin. Involved in DNA repair. Part of replication fork protection complex. Orthologous to several human genes including H2AC1 (H2A clustered histone 1); H2AC14 (H2A clustered histone 14); and H2AC15 (H2A clustered histone 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HTA2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (235394..235792, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene Utp20p Neighboring gene histone H2B Neighboring gene Ecm15p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved sequence in histone H2A which is a ubiquitination site in higher eucaryotes is not required for growth in Saccharomyces cerevisiae. Swerdlow PS, et al. Mol Cell Biol, 1990 Sep. PMID 2201907, Free PMC Article
    2. Either of the major H2A genes but not an evolutionarily conserved H2A.F/Z variant of Tetrahymena thermophila can function as the sole H2A gene in the yeast Saccharomyces cerevisiae. Liu X, et al. Mol Cell Biol, 1996 Jun. PMID 8649398, Free PMC Article
    3. Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast. Herbert S, et al. EMBO J, 2017 Sep 1. PMID 28694242, Free PMC Article
    4. Functional analysis of histones H2A and H2B in transcriptional repression in Saccharomyces cerevisiae. Recht J, et al. Mol Cell Biol, 1996 Jun. PMID 8649361, Free PMC Article
    5. The effect of histone gene deletions on chromatin structure in Saccharomyces cerevisiae. Norris D, et al. Science, 1988 Nov 4. PMID 2847314

    See all (249) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. H2A.1 promotes high-fidelity homologous recombination, sister chromatid recombination (SCR), and break-induced replication whereas H2A.2 does not share these functions. Both decreased SCR and the increase in CAG expansions were due to the unique Thr126 residue in H2A.1 and hta1Delta or hta1-T126A mutants were epistatic to deletion of the Poldelta subunit Pol32, suggesting a role for H2A.1 in D-loop extension.
      Title: Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126.
    2. The data identifies novel roles of the histone H2A N-tail in (i) regulating the expression of a critical BER enzyme (Mag1), (ii) supporting efficient DNA damage signaling and (iii) facilitating postreplication repair.
      Title: The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae.
    3. H2A phosphorylation promotes two independent events, rapid Rad9 recruitment to DSBs and subsequent remodeling by NuA4, SWR, and INO80.
      Title: Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H2A
    NP_009552.1
    • Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      235394..235792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178243.1 → NP_009552.1  TPA: histone H2A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009552.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPZ9, P04912
      UniProtKB/TrEMBL
      A6ZKU5, B3LNE2, C7GM51, C8Z3Z5, G2W906, N1P913
      Conserved Domains (1) summary
      PTZ00017
      Location:18 → 131
      PTZ00017; histone H2A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04912.2

    Gene LinkOut

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