MET17 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET17
Official Full Name: bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17
Primary source: SGD:S000004294
Locus tag: YLR303W
See related: AllianceGenome:SGD:S000004294; FungiDB:YLR303W; VEuPathDB:YLR303W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MET15; MET25
Summary: Enables O-acetylhomoserine aminocarboxypropyltransferase activity and cysteine synthase activity. Involved in methionine metabolic process. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MET17 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (732542..733876)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Western analysis revealed reduced expression of Met17p in the glo1 deletion, but there was no indication of an altered conformation of Met17p or any direct interaction between the two proteins
Title: The GLO1 Gene Is Required for Full Activity of O-Acetyl Homoserine Sulfhydrylase Encoded by MET17.
The overexpression of Cdc34 accelerated the ubiquitination of the transcription factor Met4 and reduced expression of MET25 gene, which is a target of Met4.
Title: Ubiquitin-conjugating enzyme Cdc34 mediates cadmium resistance in budding yeast through ubiquitination of the transcription factor Met4.
Transgenic tobacco plants expressing the yeast MET25 gene under the control of a constitutive promoter and targeted the yeast protein to the cytosol or to the chloroplasts.
Title: Transgenic tobacco plants overexpressing the Met25 gene of Saccharomyces cerevisiae exhibit enhanced levels of cysteine and glutathione and increased tolerance to oxidative stress.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables O-acetylhomoserine aminocarboxypropyltransferase activity	IEA Inferred from Electronic Annotation more info
enables O-acetylhomoserine sulfhydrylase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-acetylhomoserine sulfhydrylase activity	IEA Inferred from Electronic Annotation more info
enables cysteine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine synthase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' L-methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-homocysteine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methionine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17

NP_013406.1

EC 2.5.1.47

EC 2.5.1.49

O-acetyl homoserine-O-acetyl serine sulfhydrylase; involved in methionine and cysteine biosynthesis; long considered essential for inorganic sulfur assimilation, but inefficient homocysteine synthase Hsu1p enables met17 null cells to assimilate enough inorganic sulfur for survival and proliferation; growth failure of met17 null can be explained by toxic accumulation of H2S gas due to a metabolic bottleneck

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

732542..733876

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182191.1 → NP_013406.1 TPA: bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013406.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYU6, P06106

UniProtKB/TrEMBL

A0A0P0BRV9, A0A0P0C0N3, A7A1I7, B3RHI1, B5VNK3, C8ZDR6, N1NZZ7

Conserved Domains (1) summary

TIGR01326
Location:4 → 436

OAH_OAS_sulfhy; OAH/OAS sulfhydrylase