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    RNH203 Rnh203p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RNH203
    Official Full Name
    Rnh203p
    Primary source
    SGD:S000004144
    Locus tag
    YLR154C
    See related
    AllianceGenome:SGD:S000004144; FungiDB:YLR154C; VEuPathDB:YLR154C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA-DNA hybrid ribonuclease activity. Involved in RNA catabolic process. Located in cytoplasm and nucleus. Part of ribonuclease H2 complex. Used to study Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RNH203 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (447982..448314, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene acetate--CoA ligase ACS2 Neighboring gene tRNA-Gln Neighboring gene miscRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Jeong HS, et al. Nucleic Acids Res, 2004. PMID 14734815, Free PMC Article
    2. RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids. Lockhart A, et al. Cell Rep, 2019 Nov 26. PMID 31775053
    3. Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII. Rohman MS, et al. FEBS J, 2008 Oct. PMID 18721139, Free PMC Article
    4. Analysis of subunit assembly and function of the Saccharomyces cerevisiae RNase H2 complex. Nguyen TA, et al. FEBS J, 2011 Dec. PMID 22004424
    5. Defects in RNase H2 Stimulate DNA Break Repair by RNA Reverse Transcribed into cDNA. Keskin H, et al. Microrna, 2015. PMID 26456534

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA-DNA hybrid ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA-DNA hybrid ribonuclease activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease H2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rnh203p
    NP_013255.1
    • Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      447982..448314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182041.1 → NP_013255.1  TPA: Rnh203p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYE9, Q12338, Q6Q5B9
      UniProtKB/TrEMBL
      B3LTB5, C7GMK6, C8ZDC5, G2WIZ3, N1P191
      Conserved Domains (1) summary
      cl07291
      Location:14 → 90
      RNase_H2-C; Ribonuclease H2-C is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12338.1

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