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    STM1 Stm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850843, updated on 17-Dec-2024

    Summary

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    Official Symbol
    STM1
    Official Full Name
    Stm1p
    Primary source
    SGD:S000004140
    Locus tag
    YLR150W
    See related
    AllianceGenome:SGD:S000004140; FungiDB:YLR150W; VEuPathDB:YLR150W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MPT4
    Summary
    Enables ribosome binding activity; telomeric DNA binding activity; and triplex DNA binding activity. Involved in several processes, including TOR signaling; regulation of translational initiation in response to stress; and translational elongation. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STM1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (440467..441288)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tethering complex subunit PEP3 Neighboring gene Gid11p Neighboring gene 8-oxo-dGTP diphosphatase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae. Correia H, et al. Mem Inst Oswaldo Cruz, 2004 Nov. PMID 15654430
    2. The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence. Van Dyke N, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23206692
    3. A yeast gene product, G4p2, with a specific affinity for quadruplex nucleic acids. Frantz JD, et al. J Biol Chem, 1995 Apr 21. PMID 7721866
    4. Stm1p, a ribosome-associated protein, is important for protein synthesis in Saccharomyces cerevisiae under nutritional stress conditions. Van Dyke N, et al. J Mol Biol, 2006 May 12. PMID 16580682
    5. The yeast STM1 gene encodes a purine motif triple helical DNA-binding protein. Nelson LD, et al. J Biol Chem, 2000 Feb 25. PMID 10681538

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.
      Title: TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.
    2. These findings suggest that Stm1p can act as a ribosome preservation factor under conditions of nutrient deprivation and restoration.
      Title: The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence.
    3. Stm1 may recognize the shape of the triplex rather than the base sequence of the triplex.
      Title: The interaction between the purine motif triplex and the triplex DNA-binding domain of Saccharomyces cerevisiae Stm1 protein.
    4. data indicates that Stm1p plays a complementary role to eEF3 in translation.
      Title: Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation.
    5. Stm1 loss-of-function alleles and overexpression strains show several genetic interactions with Pat1 and Dhh1 alleles in a manner consistent with Stm1 working upstream of Dhh1 to promote Dhh1 function.
      Title: Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae.
    6. Stm(amino acids 1-113) is the minimal domain to specifically bind with the purine motif triplex.
      Title: Location of the triplex DNA-binding domain of Saccharomyces cerevisiae Stm1 protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triplex DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Stm1p
    NP_013251.1
    • Ribosome preservation factor; required for optimal translation under nutrient stress; forms dormant 80S ribosomes upon TORC1 inhibition, protects ribosomes from proteasomal degradation; perturbs association of Yef3p with ribosomes; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      440467..441288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182037.1 → NP_013251.1  TPA: Stm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013251.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYE5, P39015
      UniProtKB/TrEMBL
      A7A149, B3LTB1, B5VN78, C7GMK2, G2WIY9, N1NZQ8
      Conserved Domains (1) summary
      pfam09598
      Location:3 → 53
      Stm1_N
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39015.3

    Gene LinkOut

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