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    SPE4 spermine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPE4
    Official Full Name
    spermine synthase
    Primary source
    SGD:S000004136
    Locus tag
    YLR146C
    See related
    AllianceGenome:SGD:S000004136; FungiDB:YLR146C; VEuPathDB:YLR146C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables spermine synthase activity. Involved in pantothenate biosynthetic process and spermine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPE4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (432823..433725, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene endo-1,3(4)-beta-glucanase Neighboring gene Rmp1p Neighboring gene uncharacterized protein Neighboring gene mRNA splicing protein SMD3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spermine is not essential for growth of Saccharomyces cerevisiae: identification of the SPE4 gene (spermine synthase) and characterization of a spe4 deletion mutant. Hamasaki-Katagiri N, et al. Gene, 1998 Apr 14. PMID 9573363
    2. Regulatory mutations affecting ornithine decarboxylase activity in Saccharomyces cerevisiae. Cohn MS, et al. J Bacteriol, 1980 Jun. PMID 6991493, Free PMC Article
    3. Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism. Olin-Sandoval V, et al. Nature, 2019 Aug. PMID 31367038, Free PMC Article
    4. Disruption of six Saccharomyces cerevisiae ORFs on chromosome XII results in three lethal disruptants. Alloush HM, et al. Yeast, 2002 Jan 15. PMID 11754485
    5. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. White WH, et al. J Biol Chem, 2001 Apr 6. PMID 11154694

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spermine synthase
    NP_013247.1
    • Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      432823..433725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182033.1 → NP_013247.1  TPA: spermine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYE0, Q12455, Q2VQW3
      UniProtKB/TrEMBL
      A7A144, B3LTA6, C7GMJ7, C8ZDB5, N1NZQ6
      Conserved Domains (1) summary
      TIGR00417
      Location:14 → 293
      speE; spermidine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12455.1

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