CRM1 exportin CRM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CRM1
Official Full Name: exportin CRM1
Primary source: SGD:S000003450
Locus tag: YGR218W
See related: AllianceGenome:SGD:S000003450; FungiDB:YGR218W; VEuPathDB:YGR218W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KAP124; XPO1
Summary: Enables nuclear import signal receptor activity and snRNA binding activity. Involved in nuclear export and protein localization to kinetochore. Acts upstream of or within tRNA re-export from nucleus. Located in kinetochore; nucleus; and spindle pole body. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CRM1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (932541..935795)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exportin Crm1 is important for Swi6 nuclear shuttling and MBF transcription activation in Saccharomyces cerevisiae.
Title: Exportin Crm1 is important for Swi6 nuclear shuttling and MBF transcription activation in Saccharomyces cerevisiae.
Crystal structure of the Xpo1p nuclear export complex identified three Xpo1-Nup42 interaction sites.
Title: Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p.
The exportin Crm1 is also required for the same pre-ribosome maturation events that involve Rrp12. Thus, in addition to their implication in nuclear export, Rrp12 and Crm1 participate in earlier biosynthetic steps that take place in the nucleolus.
Title: Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis.
The structure shows that on association of Ran-binding domain (RanBD) of RanBP1 with CRM1:NES-cargo:RanGTP complex, RanBD and the C-terminal acidic tail of Ran induce a large movement of the intra-HEAT9 loop of CRM1.
Title: An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.
Hxk2 phosphorylation at serine 14 promotes Hxk2 export by facilitating the association of Hxk2 with Xpo1.
Title: Nuclear export of the yeast hexokinase 2 protein requires the Xpo1 (Crm1)-dependent pathway.
A functional link between Xpo1 and the spindle pole body and a role for this exportin in spindle biogenesis in budding yeast, is proposed.
Title: Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast.
In the daughter cell nucleus Cbk1p phosphorylates the Ace2p nuclear export signal, and the phosphorylation blocks the export of Ace2p via Crm1p.
Title: Mutations in a small region of the exportin Crm1p disrupt the daughter cell-specific nuclear localization of the transcription factor Ace2p in Saccharomyces cerevisiae.
Our results suggest a requirement for Crm1p-dependent nuclear export of Cdc14p in coordinating mitotic exit and cytokinesis in budding yeast.
Title: Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast.
cytoplasmic location of Arc1p is maintained by Xpo1p-dependent nuclear export
Title: The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables U1 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U2 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U4 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U5 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U6 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear export signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear import signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear import signal receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tRNA re-export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: exportin CRM1

NP_011734.3

Nuclear export factor, exportin; major karyopherin involved in export of proteins, RNAs, and ribosomal subunits from the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

932541..935795

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181347.3 → NP_011734.3 TPA: exportin CRM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011734.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV01, P30822

UniProtKB/TrEMBL

A6ZUM9, B3LI19, B5VJF8, C7GNK8, C8Z9B0, G2WEU7, N1P648

Conserved Domains (1) summary

COG5101
Location:1 → 1070

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]