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    IZH1 PAQR-type receptor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IZH1
    Official Full Name
    PAQR-type receptor
    Primary source
    SGD:S000002900
    Locus tag
    YDR492W
    See related
    AllianceGenome:SGD:S000002900; FungiDB:YDR492W; VEuPathDB:YDR492W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable signaling receptor activity. Involved in intracellular zinc ion homeostasis. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; and prostate adenocarcinoma. Orthologous to human ADIPOR1 (adiponectin receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IZH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1434924..1435874)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA replication protein SLD5 Neighboring gene serine/threonine protein kinase PKH1 Neighboring gene Mzm1p Neighboring gene mitochondrial 37S ribosomal protein RSM28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Narasimhan ML, et al. Mol Cell, 2005 Jan 21. PMID 15664187
    2. Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets. Villa NY, et al. J Mol Evol, 2011 Oct. PMID 22009226, Free PMC Article
    3. Metalloregulation of yeast membrane steroid receptor homologs. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15060275, Free PMC Article
    4. An Autophagy-Independent Role for ATG41 in Sulfur Metabolism During Zinc Deficiency. Bucci MD, et al. Genetics, 2018 Mar. PMID 29321173, Free PMC Article
    5. The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. Kim JH, et al. J Biol Chem, 2009 Apr 17. PMID 19233841, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PAQR-type receptor
    NP_010780.1
    • Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1434924..1435874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180800.1 → NP_010780.1  TPA: PAQR-type receptor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTB4, Q03419, Q6Q557
      UniProtKB/TrEMBL
      B3LFH5, B5VH19, C7GKS9, C8Z650, G2WBM0, N1PAL2
      Conserved Domains (1) summary
      pfam03006
      Location:75 → 300
      HlyIII; Haemolysin-III related
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03419.1

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