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    SDC1 Sdc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDC1
    Official Full Name
    Sdc1p
    Primary source
    SGD:S000002877
    Locus tag
    YDR469W
    See related
    AllianceGenome:SGD:S000002877; FungiDB:YDR469W; VEuPathDB:YDR469W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CPS25; SAF19
    Summary
    Contributes to histone H3K4 methyltransferase activity. Involved in subtelomeric heterochromatin formation. Part of Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDC1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1399015..1399542)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein kinase PKH3 Neighboring gene Tlg1p Neighboring gene Ugo1p Neighboring gene ribosomal 60S subunit protein L27B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Sun ZW, et al. Nature, 2002 Jul 4. PMID 12077605
    2. A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. South PF, et al. J Biol Chem, 2010 Jan 1. PMID 19897479, Free PMC Article
    3. Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination. Huang F, et al. J Biol Chem, 2015 Nov 27. PMID 26451043, Free PMC Article
    4. Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Hsu PL, et al. Cell, 2018 Aug 23. PMID 30100181, Free PMC Article
    5. Molecular basis for DPY-30 association to COMPASS-like and NURF complexes. Tremblay V, et al. Structure, 2014 Dec 2. PMID 25456412, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bre2 and Sdc1 are shown to directly interact, and it is shown that the association of this heteromeric complex is needed for proper H3K4 methylation and gene expression to occur.
      Title: A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H3K4 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sdc1p
    NP_010757.3
    • Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1399015..1399542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180777.3 → NP_010757.3  TPA: Sdc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010757.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT93, Q03323
      UniProtKB/TrEMBL
      A6ZZ59, B3LFJ6, B5VGZ8, C7GKR0, C8Z628, G2WBJ9, N1P8Z7
      Conserved Domains (1) summary
      pfam05186
      Location:122 → 162
      Dpy-30; Dpy-30 motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03323.1

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