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    CWC15 U2-type spliceosomal complex subunit CWC15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CWC15
    Official Full Name
    U2-type spliceosomal complex subunit CWC15
    Primary source
    SGD:S000002570
    Locus tag
    YDR163W
    See related
    AllianceGenome:SGD:S000002570; FungiDB:YDR163W; VEuPathDB:YDR163W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U2-type spliceosomal complex. Orthologous to human CWC15 (CWC15 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CWC15 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (781423..781950)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Acl4p Neighboring gene Nbp2p Neighboring gene Sec1p Neighboring gene Trm82p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Prp19C/NTC subunit Syf2 and the Prp19C/NTC-associated protein Cwc15 function in TREX occupancy and transcription elongation. Henke-Schulz L, et al. RNA, 2024 Jun 17. PMID 38627018, Free PMC Article
    2. The Spliceosome: A Protein-Directed Metalloribozyme. Shi Y. J Mol Biol, 2017 Aug 18. PMID 28733144
    3. Decrypting the Information Exchange Pathways across the Spliceosome Machinery. Saltalamacchia A, et al. J Am Chem Soc, 2020 May 6. PMID 32275149, Free PMC Article
    4. Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae. Bai R, et al. Cell, 2017 Dec 14. PMID 29153833
    5. Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae. Wan R, et al. Cell, 2017 Sep 21. PMID 28919079

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2-type spliceosomal complex subunit CWC15
    NP_010447.3
    • Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      781423..781950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180470.3 → NP_010447.3  TPA: U2-type spliceosomal complex subunit CWC15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010447.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSE3, Q03772
      UniProtKB/TrEMBL
      A6ZYC1, B3LGC1, C7GQF6, C8Z577, G2WAR1
      Conserved Domains (1) summary
      pfam04889
      Location:1 → 123
      Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03772.1

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