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    Nadk1a NAD kinase 1a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nadk1aprovided by FlyBase
    Official Full Name
    NAD kinase 1aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033853
    Locus tag
    Dmel_CG6145
    See related
    AllianceGenome:FB:FBgn0033853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6145; CT19307; Dmel\CG6145; NADK
    Summary
    Enables NAD+ kinase activity. Involved in NADP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in adult brain. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nadk1a in Genome Data Viewer
    Location:
    50B1-50B1; 2-68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13537371..13547577, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9424876..9435082, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vesicular monoamine transporter Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Lysine-CTT 1-10 Neighboring gene NAD kinase 1b Neighboring gene Roe1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Curly Encodes Dual Oxidase, Which Acts with Heme Peroxidase Curly Su to Shape the Adult Drosophila Wing. Hurd TR, et al. PLoS Genet, 2015 Nov. PMID 26587980, Free PMC Article
    2. NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis. Xu M, et al. Cell Rep, 2021 Dec 28. PMID 34965438
    3. A kinase-dependent feedforward loop affects CREBB stability and long term memory formation. Lee PT, et al. Elife, 2018 Feb 23. PMID 29473541, Free PMC Article
    4. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article
    5. Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila. Beckstead RB, et al. Insect Biochem Mol Biol, 2007 Jun. PMID 17517334, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NAD+ kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NADP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NAD kinase 1a
    Names
    CG6145-PA
    CG6145-PB
    CG6145-PC
    CG6145-PE
    CG6145-PF
    NAD kinase
    Nadk1a-PA
    Nadk1a-PB
    Nadk1a-PC
    Nadk1a-PE
    Nadk1a-PF
    NP_001163145.1
    NP_001163146.1
    NP_610884.1
    NP_725314.1
    NP_725315.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13537371..13547577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169674.2 → NP_001163145.1  NAD kinase 1a, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH60
      Conserved Domains (1) summary
      cl01255
      Location:81 → 454
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. NM_137040.4 → NP_610884.1  NAD kinase 1a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9F0
      Related
      FBpp0086805
      Conserved Domains (1) summary
      cl01255
      Location:118 → 491
      DAGK_cat; Diacylglycerol kinase catalytic domain

    3. NM_166003.3 → NP_725314.1  NAD kinase 1a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDH2
      Related
      FBpp0086806
      Conserved Domains (1) summary
      cl01255
      Location:146 → 519
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. NM_166004.3 → NP_725315.1  NAD kinase 1a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZX5
      Related
      FBpp0086807
      Conserved Domains (1) summary
      cl01255
      Location:18 → 391
      DAGK_cat; Diacylglycerol kinase catalytic domain

    5. NM_001169675.2 → NP_001163146.1  NAD kinase 1a, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH61
      Conserved Domains (1) summary
      cl01255
      Location:82 → 455
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9F0 A1Z9F0
    E1JH60 E1JH60
    E1JH61 E1JH61
    Q6IDH2 Q6IDH2
    Q8SZX5 Q8SZX5

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