Set2 SET domain containing 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Set2provided by FlyBase
Official Full Name: SET domain containing 2provided by FlyBase
Primary source: FLYBASE:FBgn0030486
Locus tag: Dmel_CG1716
See related: AllianceGenome:FB:FBgn0030486
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1716; dHypb; Dmel\CG1716; dSet2; Hypb; SET-2; set2; SET2
Summary: Enables histone H3K36 trimethyltransferase activity and phosphoprotein binding activity. Involved in several processes, including ecdysone receptor signaling pathway; instar larval development; and retrotransposon silencing by heterochromatin formation. Located in nucleus. Is expressed in embryonic/larval midgut and organism. Used to study cancer. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; carcinoma (multiple); gastrointestinal system cancer (multiple); idiopathic pulmonary fibrosis; and malignant mesothelioma. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13413242..13421024)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13307275..13315057)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A missense SNP in the tumor suppressor SETD2 reduces H3K36me3 and mitotic spindle integrity in Drosophila.
Title: A missense SNP in the tumor suppressor SETD2 reduces H3K36me3 and mitotic spindle integrity in Drosophila.
IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2.
Title: IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2.
CG4747 and Set2 function together to facilitate targeting of the male-specific lethal complex to active genes.
Title: Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.
dSet2 associates with the hyperphosphorylated form of RNA polymerase II (RNAPII)
Title: Drosophila dSet2 functions in H3-K36 methylation and is required for development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone H3K36 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K36 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K36 trimethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36 trimethyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K4 dimethyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in ecdysone receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in transposable element silencing by heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_001162740.1

NP_572888.2

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