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    prod proliferation disrupter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37187, updated on 17-Dec-2024

    Summary

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    Official Symbol
    prodprovided by FlyBase
    Official Full Name
    proliferation disrupterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014269
    Locus tag
    Dmel_CG18608
    See related
    AllianceGenome:FB:FBgn0014269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18608; Dmel\CG18608; l(2)88/10; l(2)k08810; Prod; PROD; Rrod
    Summary
    Involved in lymph gland development; mitotic chromosome condensation; and regulation of circadian rhythm. Located in euchromatin and pericentric heterochromatin. Is expressed in several structures, including central brain primordium; ganglia; mesoderm; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prod in Genome Data Viewer
    Location:
    56A2-56A2; 2-87 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18969404..18971133, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14856909..14858638, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Diptericin B Neighboring gene serrano Neighboring gene Vacuolar H[+] ATPase 100kD subunit 3 Neighboring gene uncharacterized protein Neighboring gene Topoisomerase I-interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centromere-proximal suppression of meiotic crossovers in Drosophila is robust to changes in centromere number, repetitive DNA content, and centromere-clustering. Pazhayam NM, et al. Genetics, 2024 Mar 6. PMID 38150397, Free PMC Article
    2. Prod is a novel DNA-binding protein that binds to the 1.686 g/cm(3) 10 bp satellite repeat of Drosophila melanogaster. Török T, et al. Nucleic Acids Res, 2000 Sep 15. PMID 10982875, Free PMC Article
    3. The protein encoded by the gene proliferation disrupter (prod) is associated with the telomeric retrotransposon array in Drosophila melanogaster. Török T, et al. Chromosoma, 2007 Apr. PMID 17186256
    4. Centromeres: proteins, protein complexes, and repeated domains at centromeres of simple eukaryotes. Clarke L. Curr Opin Genet Dev, 1998 Apr. PMID 9610412
    5. The product of proliferation disrupter is concentrated at centromeres and required for mitotic chromosome condensation and cell proliferation in Drosophila. Török T, et al. Genes Dev, 1997 Jan 15. PMID 9009204

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proliferation disrupter
    Names
    CG18608-PA
    prod-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18969404..18971133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166317.2 → NP_725841.1  proliferation disrupter [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725841.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JNE1
      Related
      FBpp0085785
      Conserved Domains (1) summary
      pfam13873
      Location:8 → 83
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JNE1 Q7JNE1
    Q7KYA8 Q7KYA8
    Q7KYD3 Q7KYD3

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