Sec8 Secretory 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sec8provided by FlyBase
Official Full Name: Secretory 8provided by FlyBase
Primary source: FLYBASE:FBgn0266672
Locus tag: Dmel_CG2095
See related: AllianceGenome:FB:FBgn0266672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2095; Dmel\CG2095; dsec8; fun; sec8; Sec8p
Summary: Involved in several processes, including cytoskeleton-dependent cytokinesis; germ cell development; and positive regulation of synaptic assembly at neuromuscular junction. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and rhabdomere. Part of exocyst. Is expressed in adult head and spermatid cyst. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83C2-83C2; 3-47.5 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5754932..5758997, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1580654..1584719, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec5, Sec6 and Sec8 act as a complex, each member dependent on the others for proper localization and function
Title: Sec6 mutations and the Drosophila exocyst complex.
No evidence that Sec8 is required for basal neurotransmission, though glutamate receptor trafficking was mildly disrupted in sec8 mutants.
Title: Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiosis I cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis II cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in plasma membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in synaptic vesicle docking	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle targeting	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle docking involved in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in vesicle tethering involved in exocytosis	IC Inferred by Curator more info	PubMed
involved_in vesicle tethering involved in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IEA Inferred from Electronic Annotation more info
part_of exocyst	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
is_active_in growth cone membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: secretory 8

Names: CG2095-PA; Sec8 ortholog; Sec8-PA; funnel cakes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5754932..5758997 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169098.4 → NP_730996.2 secretory 8 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730996.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5ECP5, Q9VNH6

UniProtKB/TrEMBL

U3PXA7

Related

FBpp0078326

Conserved Domains (2) summary

pfam02828
Location:156 → 207

L27; L27 domain

pfam04048
Location:32 → 143

Sec8_exocyst; Sec8 exocyst complex component specific domain