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    Panx Panoramix [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Panxprovided by FlyBase
    Official Full Name
    Panoramixprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034617
    Locus tag
    Dmel_CG9754
    See related
    AllianceGenome:FB:FBgn0034617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9754; Dmel\CG9754; pan; panx
    Summary
    Enables piRNA binding activity and transcription corepressor activity. Involved in piRNA-mediated retrotransposon silencing by heterochromatin formation and positive regulation of DNA methylation-dependent heterochromatin formation. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Panx in Genome Data Viewer
    Location:
    57D11-57D11; 2-94 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21310368..21312354, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17197873..17199859, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44724 Neighboring gene Ankyrin repeat-rich membrane spanning Neighboring gene antisense RNA:CR45149 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis. Fabry MH, et al. Elife, 2021 Jul 8. PMID 34236313, Free PMC Article
    2. piRNA-independent transposon silencing by the Drosophila THO complex. Zhang G, et al. Dev Cell, 2021 Sep 27. PMID 34547226, Free PMC Article
    3. piRNA-guided co-transcriptional silencing coopts nuclear export factors. Fabry MH, et al. Elife, 2019 Jun 20. PMID 31219034, Free PMC Article
    4. The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation. Batki J, et al. Nat Struct Mol Biol, 2019 Aug. PMID 31384064, Free PMC Article
    5. Pervasive SUMOylation of heterochromatin and piRNA pathway proteins. Ninova M, et al. Cell Genom, 2023 Jul 12. PMID 37492097, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
      Title: Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
    2. SFiNX, an interdependent protein complex, is required for Piwi-mediated cotranscriptional silencing in Drosophila. SFiNX consists of Nxf2-Nxt1, a gonad-specific variant of the heterodimeric messenger RNA export receptor Nxf1-Nxt1 and the Piwi-associated protein Panoramix. Within SFiNX, Panoramix recruits heterochromatin effectors, while the RNA binding protein Nxf2 licenses cotranscriptional silencing.
      Title: The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
    3. The transposon RNA-binding protein Nxf2 is required for animal fertility and Panoramix-mediated silencing.
      Title: A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.
    4. CG9754/Silencio as an essential piRNA pathway factor that is required for Piwi-mediated transcriptional silencing in Drosophila
      Title: Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery.
    5. this study sshow that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in transcriptional silencing.
      Title: Panoramix enforces piRNA-dependent cotranscriptional silencing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables piRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transposable element silencing by heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transposable element silencing by piRNA-mediated heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transposable element silencing by piRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    panoramix
    Names
    CG9754-PA
    Panx-PA
    silencio

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21310368..21312354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137732.4 → NP_611576.1  panoramix [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W2H9
      Related
      FBpp0071541
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2H9.1 Q9W2H9

    Gene LinkOut

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