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    Aasdh Aminoadipate-semialdehyde dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aasdhprovided by FlyBase
    Official Full Name
    Aminoadipate-semialdehyde dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027780
    Locus tag
    Dmel_CG13401
    See related
    AllianceGenome:FB:FBgn0027780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13401; Dmel\CG13401; U26
    Summary
    Predicted to enable beta-alanyl amine synthase activity. Predicted to be involved in amino acid activation for nonribosomal peptide biosynthetic process and fatty acid metabolic process. Orthologous to human AASDH (aminoadipate-semialdehyde dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aasdh in Genome Data Viewer
    Location:
    29C5-29C5; 2-32 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8445861..8449576, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8445861..8449576, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mutagen-sensitive 201 Neighboring gene uncharacterized protein Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene piragua

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutritional biochemistry: A new redox-cofactor vitamin for mammals. Kasahara T, et al. Nature, 2003 Apr 24. PMID 12712191
    2. GeneFizz: A web tool to compare genetic (coding/non-coding) and physical (helix/coil) segmentations of DNA sequences. Gene discovery and evolutionary perspectives. Yeramian E, et al. Nucleic Acids Res, 2003 Jul 1. PMID 12824434, Free PMC Article
    3. Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin. Cox RT, et al. Dis Model Mech, 2009 Sep-Oct. PMID 19638420, Free PMC Article
    4. Age-related ceRNA networks in adult Drosophila ageing. Yang D, et al. Front Genet, 2023. PMID 36926584, Free PMC Article
    5. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. U26 is involved in the lysine degradation pathway
      Title: Nutritional biochemistry: A new redox-cofactor vitamin for mammals.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-alanyl amine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid activation for nonribosomal peptide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Aminoadipate-semialdehyde dehydrogenase
    Names
    Aasdh-PA
    Aasdh-PC
    Aasdh-PD
    CG13401-PA
    CG13401-PC
    CG13401-PD
    U26

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8445861..8449576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135386.5 → NP_609230.2  Aminoadipate-semialdehyde dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609230.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1RKX6, Q9U973, Q9VLL0
      UniProtKB/TrEMBL
      F0JAI7
      Related
      FBpp0088615
      Conserved Domains (4) summary
      TIGR01733
      Location:46 → 443
      AA-adenyl-dom; amino acid adenylation domain
      pfam13360
      Location:732 → 978
      PQQ_2; PQQ-like domain
      cl11493
      Location:728 → 1012
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:168 → 522
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_001298825.1 → NP_001285754.1  Aminoadipate-semialdehyde dehydrogenase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J591
      Conserved Domains (1) summary
      cl17068
      Location:168 → 299
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. NM_205938.2 → NP_995660.2  Aminoadipate-semialdehyde dehydrogenase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995660.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1RKX6, Q9U973, Q9VLL0
      UniProtKB/TrEMBL
      F0JAI7
      Conserved Domains (4) summary
      TIGR01733
      Location:46 → 443
      AA-adenyl-dom; amino acid adenylation domain
      pfam13360
      Location:732 → 978
      PQQ_2; PQQ-like domain
      cl11493
      Location:728 → 1012
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
      cl17068
      Location:168 → 522
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLL0.3 Q9VLL0
    X2J591 X2J591

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