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    Nckx30C Nckx30C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nckx30Cprovided by FlyBase
    Official Full Name
    Nckx30Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028704
    Locus tag
    Dmel_CG18660
    See related
    AllianceGenome:FB:FBgn0028704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18660; CG4106; Dmel\CG18660; Nck; Nckx30c; NckX30C; NcKx30C; NcKX30C; potassium-dependent sodium/calcium
    Summary
    Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport; compound eye development; and sodium ion transport. Located in membrane. Is expressed in several structures, including adult optic lobe; brain; head; imaginal disc; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1D. Orthologous to several human genes including SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nckx30C in Genome Data Viewer
    Location:
    30C6-30C7; 2-36 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9711512..9746495, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9711512..9746495, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pelota Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46529 Neighboring gene Cytochrome P450 4e3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a potassium-dependent sodium/calcium exchanger in Drosophila. Haug-Collet K, et al. J Cell Biol, 1999 Nov 1. PMID 10545508, Free PMC Article
    2. Potassium-dependent sodium-calcium exchange through the eye of the fly. Webel R, et al. Ann N Y Acad Sci, 2002 Nov. PMID 12502573
    3. Molecular characterization, functional expression and tissue distribution of a second NCKX Na+/Ca2+ -K+ exchanger from Drosophila. Winkfein RJ, et al. Cell Calcium, 2004 Aug. PMID 15193862
    4. Drosophila HisT is a specific histamine transporter that contributes to histamine recycling in glia. Xie J, et al. Sci Adv, 2022 Oct 28. PMID 36288320, Free PMC Article
    5. Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease. Bhatnagar A, et al. J Neurosci, 2023 Mar 29. PMID 36849418, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. physiology of this protein in Drosophila eye (REVIEW)
      Title: Potassium-dependent sodium-calcium exchange through the eye of the fly.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium, potassium:sodium antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in compound eye development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nckx30C
    Names
    CG18660-PA
    CG18660-PB
    CG18660-PD
    CG18660-PE
    CG18660-PF
    Nckx30C-PA
    Nckx30C-PB
    Nckx30C-PD
    Nckx30C-PE
    Nckx30C-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9711512..9746495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273367.1 → NP_001260296.1  Nckx30C, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCP1
      Conserved Domains (2) summary
      TIGR00367
      Location:335 → 831
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:687 → 837
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_143754.5 → NP_652011.3  Nckx30C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652011.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0I2, C7LAF4, Q8IPE3, Q8SXD2, Q9U6A0, Q9VL95
      Conserved Domains (1) summary
      pfam01699
      Location:721 → 871
      Na_Ca_ex; Sodium/calcium exchanger protein

    3. NM_001201832.2 → NP_001188761.1  Nckx30C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188761.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRG0
      Conserved Domains (1) summary
      pfam01699
      Location:712 → 862
      Na_Ca_ex; Sodium/calcium exchanger protein

    4. NM_164870.3 → NP_723483.1  Nckx30C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U6A0
      Related
      FBpp0079516
      Conserved Domains (2) summary
      TIGR00367
      Location:335 → 840
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:696 → 846
      Na_Ca_ex; Sodium/calcium exchanger protein

    5. NM_164869.3 → NP_723482.1  Nckx30C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U6A0
      Related
      FBpp0079518
      Conserved Domains (2) summary
      TIGR00367
      Location:335 → 840
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:696 → 846
      Na_Ca_ex; Sodium/calcium exchanger protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRG0 M9MRG0
    M9PCP1 M9PCP1
    Q9U6A0.4 Q9U6A0

    Gene LinkOut

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