U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mppe Metallophosphoesterase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36285, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mppeprovided by FlyBase
    Official Full Name
    Metallophosphoesteraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259985
    Locus tag
    Dmel_CG8889
    See related
    AllianceGenome:FB:FBgn0259985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    11471; CG8889; Dmel\CG8889; dmppe; dMPPE; GS11471; MPPE
    Summary
    Enables protein serine/threonine phosphatase activity. Predicted to be involved in GPI anchor biosynthetic process. Located in Golgi apparatus. Is expressed in adult head; eye; organism; photoreceptor neurons; and retina. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mppe in Genome Data Viewer
    Location:
    48D7-48D7; 2-65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12025614..12027707, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7913119..7915212, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene off-track Neighboring gene long non-coding RNA:CR44306 Neighboring gene off-track2 Neighboring gene precocious dissociation of sisters 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells. Fujii S, et al. J Cell Sci, 2020 Feb 26. PMID 31974113
    2. A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. Cao J, et al. EMBO J, 2011 Jul 29. PMID 21804530, Free PMC Article
    3. Phosphorylation of the Drosophila transient receptor potential ion channel is regulated by the phototransduction cascade and involves several protein kinases and phosphatases. Voolstra O, et al. PLoS One, 2013. PMID 24040070, Free PMC Article
    4. The N's and O's of Drosophila glycoprotein glycobiology. Katoh T, et al. Glycoconj J, 2013 Jan. PMID 22936173, Free PMC Article
    5. Blood-brain barrier defects associated with Rbp9 mutation. Kim J, et al. Mol Cells, 2010 Jan. PMID 20069381

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    metallophosphoesterase
    Names
    CG8889-PA
    CG8889-PB
    CG8889-PD
    CG8889-PE
    Mppe-PA
    Mppe-PB
    Mppe-PD
    Mppe-PE
    drosophila metallophosphoesterase
    NP_001286326.1
    NP_001286327.1
    NP_612572.3
    NP_725099.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12025614..12027707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138562.3 → NP_612572.3  metallophosphoesterase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612572.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T085, Q9V645
      Related
      FBpp0087131
      Conserved Domains (1) summary
      cd08166
      Location:52 → 282
      MPP_Cdc1_like_1; uncharacterized subgroup related to Saccharomyces cerevisiae CDC1, metallophosphatase domain

    2. NM_001299397.1 → NP_001286326.1  metallophosphoesterase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286326.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG64
      Conserved Domains (2) summary
      cd08166
      Location:52 → 291
      MPP_Cdc1_like_1; uncharacterized subgroup related to Saccharomyces cerevisiae CDC1, metallophosphatase domain
      pfam00149
      Location:50 → 244
      Metallophos; Calcineurin-like phosphoesterase

    3. NM_165861.2 → NP_725099.2  metallophosphoesterase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725099.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8S4
      Related
      FBpp0087132
      Conserved Domains (2) summary
      cd08166
      Location:54 → 284
      MPP_Cdc1_like_1; uncharacterized subgroup related to Saccharomyces cerevisiae CDC1, metallophosphatase domain
      pfam00149
      Location:52 → 237
      Metallophos; Calcineurin-like phosphoesterase

    4. NM_001299398.1 → NP_001286327.1  metallophosphoesterase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF50
      Conserved Domains (2) summary
      cd08166
      Location:54 → 293
      MPP_Cdc1_like_1; uncharacterized subgroup related to Saccharomyces cerevisiae CDC1, metallophosphatase domain
      pfam00149
      Location:52 → 246
      Metallophos; Calcineurin-like phosphoesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF50 A0A0B4LF50
    A0A0B4LG64 A0A0B4LG64
    A1Z8S4 A1Z8S4
    Q8T085 Q8T085

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools