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    BNIP3 BNIP3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40278, updated on 17-Dec-2024

    Summary

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    Official Symbol
    BNIP3provided by FlyBase
    Official Full Name
    BNIP3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037007
    Locus tag
    Dmel_CG5059
    See related
    AllianceGenome:FB:FBgn0037007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BBH1; Bnip3; CG5059; Dmel\CG5059
    Summary
    Predicted to enable mitochondrion autophagosome adaptor activity. Involved in mitophagy. Located in nucleus. Is expressed in several structures, including adult brain cell body rind; anlage in statu nascendi; extraembryonic structure; head epidermis primordium; and visceral mesoderm derivative. Orthologous to several human genes including BNIP3 (BCL2 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BNIP3 in Genome Data Viewer
    Location:
    77C6-77C6; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20514598..20519393, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20507698..20512493, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial transcription termination factor 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acheron/Larp6 Is a Survival Protein That Protects Skeletal Muscle From Programmed Cell Death During Development. Sheel A, et al. Front Cell Dev Biol, 2020. PMID 32850788, Free PMC Article
    2. The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress. Jeong DJ, et al. Exp Mol Med, 2024 Mar. PMID 38443598, Free PMC Article
    3. Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. Lieber T, et al. Nature, 2019 Jun. PMID 31092924, Free PMC Article
    4. PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development. Wang R, et al. Cell, 2023 Sep 14. PMID 37633267, Free PMC Article
    5. Drosophila as a Model for Tumor-Induced Organ Wasting. Saavedra P, et al. Adv Exp Med Biol, 2019. PMID 31520356

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
      Title: The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mitochondrion autophagosome adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial outer membrane permeabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BNIP3
    Names
    BNIP3-PA
    BNIP3-PB
    BNIP3-PC
    BNIP3-PD
    BNIP3-PE
    CG5059-PA
    CG5059-PB
    CG5059-PC
    CG5059-PD
    CG5059-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20514598..20519393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206403.2 → NP_996125.1  BNIP3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DN08, Q8IPU7
      Conserved Domains (1) summary
      pfam06553
      Location:1 → 175
      BNIP3; BNIP3

    2. NM_168864.2 → NP_730551.1  BNIP3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DN08, Q8IPU8
      Related
      FBpp0077876
      Conserved Domains (1) summary
      pfam06553
      Location:7 → 191
      BNIP3; BNIP3

    3. NM_001275188.1 → NP_001262117.1  BNIP3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DN08, Q8IPU7
      Conserved Domains (1) summary
      pfam06553
      Location:1 → 175
      BNIP3; BNIP3

    4. NM_140982.2 → NP_649239.1  BNIP3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DN08, Q9VPD6
      Related
      FBpp0077874
      Conserved Domains (1) summary
      pfam06553
      Location:2 → 199
      BNIP3; BNIP3

    5. NM_168865.2 → NP_730552.1  BNIP3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DN08, Q8IPU7
      Related
      FBpp0077875
      Conserved Domains (1) summary
      pfam06553
      Location:1 → 175
      BNIP3; BNIP3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPU7 Q8IPU7
    Q8IPU8 Q8IPU8
    Q9VPD6 Q9VPD6

    Gene LinkOut

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