Pka-C3 Protein kinase, cAMP-dependent, catalytic subunit 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pka-C3provided by FlyBase
Official Full Name: Protein kinase, cAMP-dependent, catalytic subunit 3provided by FlyBase
Primary source: FLYBASE:FBgn0000489
Locus tag: Dmel_CG6117
See related: AllianceGenome:FB:FBgn0000489
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5-23; CG6117; DC2; Dmel\CG6117; Dpck; Pk72A; Pk?5; PKA; PKA C3; PKA-C-3; pka-C3; PKA-C3; PKAC3
Summary: Enables cAMP-dependent protein kinase activity. Involved in imaginal disc-derived wing morphogenesis. Is expressed in several structures, including anterior endoderm anlage; embryonic/larval optic lobe; embryonic/larval optic stalk; imaginal disc; and mesoderm. Orthologous to human PRKY (protein kinase Y-linked (pseudogene)) and PRKX (protein kinase cAMP-dependent X-linked catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 72B1-72B2; 3-43 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (15925805..15954797, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (15918905..15947897, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PKA-C3 catalytic subunit is required in two pairs of interneurons for successful mating of Drosophila.
Title: The PKA-C3 catalytic subunit is required in two pairs of interneurons for successful mating of Drosophila.
OP-modified SWS cannot release PKA-C3 and the resulting loss of PKA-C3 activity plays a crucial role in developing the delayed symptoms of organophosphate-induced delayed neuropathy but not in the acute toxicity
Title: Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c15938340-15929252 mobile_element_type = transposon:roo{}1010

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase, cAMP-dependent, catalytic subunit 3

Names: CG6117-PA; CG6117-PB; Pka-C3-PA; Pka-C3-PB; Protein-kinase-like-72A; cAMP-activated protein kinase A; cAMP-dependent protein kinase; cAMP-dependent protein kinase 3

NP_524097.2

EC 2.7.11.1

EC 2.7.11.11

NP_730083.2

EC 2.7.11.1

EC 2.7.11.11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

15925805..15954797 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079373.4 → NP_524097.2 protein kinase, cAMP-dependent, catalytic subunit 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524097.2

Status: REVIEWED

UniProtKB/TrEMBL

Q194S5

Related

FBpp0075284

Conserved Domains (2) summary

PTZ00263
Location:179 → 500

PTZ00263; protein kinase A catalytic subunit; Provisional

cd05612
Location:189 → 480

STKc_PRKX_like; Catalytic domain of PRKX-like Protein Serine/Threonine Kinases
NM_168638.3 → NP_730083.2 protein kinase, cAMP-dependent, catalytic subunit 3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730083.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P16912, Q86BP5, Q8MSN9, Q9VUV5

UniProtKB/TrEMBL

Q194S5

Related

FBpp0075283

Conserved Domains (2) summary

PTZ00263
Location:262 → 583

PTZ00263; protein kinase A catalytic subunit; Provisional

cd05612
Location:272 → 563

STKc_PRKX_like; Catalytic domain of PRKX-like Protein Serine/Threonine Kinases