Cdc42 Cell division cycle 42 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdc42provided by FlyBase
Official Full Name: Cell division cycle 42provided by FlyBase
Primary source: FLYBASE:FBgn0010341
Locus tag: Dmel_CG12530
See related: AllianceGenome:FB:FBgn0010341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cdc 42; Cdc-42; CDC-42; cdc42; CDC42; Cdc42Dm; CG12530; D-cdc42; D-Cdc42; D-CDC42; Dcdc42; DCdc42; DCDC42; Dm Cdc42; Dmcdc42; DmCDC42; Dmel\CG12530; P40793
Summary: Enables GTPase activating protein binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including generation of neurons; morphogenesis of an epithelium; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including growth cone; lamellipodium; and rhabdomere. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; female germline cell; gut section; and larval muscle cell. Used to study kidney disease and myelofibrosis. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18E1-18E1; 1-64 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19697091..19699938)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19591124..19593971)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion.
Title: RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion.
Wnt6 regulates the homeostasis of the stem cell niche via Rac1-and Cdc42-mediated noncanonical Wnt signalling pathways in Drosophila testis.
Title: Wnt6 regulates the homeostasis of the stem cell niche via Rac1-and Cdc42-mediated noncanonical Wnt signalling pathways in Drosophila testis.
analysis of how the Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
Title: A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension.
Cdc42 drives morphogenesis by conferring apical identity, Par-complex assembly and apical accumulation of Crb protein.
Title: Cdc42 defines apical identity and regulates epithelial morphogenesis by promoting apical recruitment of Par6-aPKC and Crumbs.
The evidence has been presented that the highly conserved Cdc42 Rho GTPase plays a key role in the postsynaptic Dystrophin/Dystrobrevin pathway for synaptic homeostasis.
Title: Dystrobrevin is required postsynaptically for homeostatic potentiation at the Drosophila NMJ.
Cdc42 controls protrusion formation in a cell non-autonomous manner.
Title: Non-autonomous role of Cdc42 in cell-cell communication during collective migration.
Cdc42 regulates binding of Crumbs protein to the Par-6 CRIB-PDZ module.
Title: Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.
We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development
Title: Rac1 is a novel interactor of Drosophila guanine nucleotide exchange factor GEFmeso.
A proof-of-principle experiment in which the Cdc42 GTPase associates with its alleged partner WASp within neurons during the time and space that coincide with the newly developing CNS.
Title: Imaging dynamic molecular signaling by the Cdc42 GTPase within the developing CNS.
The distinct buttoning mechanism we propose for dorsal vessel closure is elaborated through signaling pathways regulating Cdc42 activity in this cell type.
Title: Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	TAS Traceable Author Statement more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	TAS Traceable Author Statement more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
NOT involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of neuroblast polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocyst localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair outgrowth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephrocyte filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	TAS Traceable Author Statement more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in rhabdomere	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cell division cycle 42

Names: CG12530-PA; CG12530-PC; CG12530-PD; Cdc42-PA; Cdc42-PC; Cdc42-PD; Cdc42-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19697091..19699938

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258833.3 → NP_001245762.1 cell division cycle 42, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245762.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40793, Q540W4, Q9U9S3, Q9U9S4, Q9U9S5, Q9U9S6, Q9V465

UniProtKB/TrEMBL

M9NFF8

Conserved Domains (2) summary

smart00174
Location:6 → 179

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
NM_001258834.3 → NP_001245763.1 cell division cycle 42, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245763.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40793, Q540W4, Q9U9S3, Q9U9S4, Q9U9S5, Q9U9S6, Q9V465

UniProtKB/TrEMBL

M9NFF8

Conserved Domains (2) summary

smart00174
Location:6 → 179

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
NM_078690.4 → NP_523414.1 cell division cycle 42, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523414.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40793, Q540W4, Q9U9S3, Q9U9S4, Q9U9S5, Q9U9S6, Q9V465

UniProtKB/TrEMBL

M9NFF8

Related

FBpp0074520

Conserved Domains (2) summary

smart00174
Location:6 → 179

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family