Taf1 TBP-associated factor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Taf1provided by FlyBase
Official Full Name: TBP-associated factor 1provided by FlyBase
Primary source: FLYBASE:FBgn0010355
Locus tag: Dmel_CG17603
See related: AllianceGenome:FB:FBgn0010355
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00004.13; cel; cell; CG17603; d230; Dmel\CG17603; dmTAF1; dmTAF[[II]]230; dTAF1; dTAF230; dTAF250; dTAFII250; dTAF[[II]]230; dTAF[[II]]250; EfW1; l(3)84Ab; p230; SR3-5; TAF; taf1; TAF1; Taf1p; Taf200; TAF200; Taf230; TAF230; Taf250; TAF250; TAF250/230; TAFII-250; TAFII250; TAF[II]250; TAF[[II]]; TAF[[II]]230; Taf[[II]]250; TAF[[II]]250; TAF[[II]]250/230; TFIID; TFIID TAF250
Summary: Enables several functions, including histone acetyltransferase activity; ubiquitin activating enzyme activity; and ubiquitin conjugating enzyme activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. Is expressed in several structures, including embryonic/larval midgut; ganglia; male germline cell; and testis. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1L (TATA-box binding protein associated factor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 84A1-84A1; 3-48 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (6646889..6656048)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2472611..2481770)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAF1 is involved in both establishing an upper limit of transcription during induction and efficiently turning the gene off once the inducer is removed
Title: Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.
The existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, is shown.
Title: Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex.
TAF1 pre-mRNA elements identified in this study are independently targeted by developmental signaling pathways to result in tissue-specific inclusion of exon 12a and/or 13a.
Title: A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing.
results suggest stepwise assembly of a testis-specific TFIID complex (tTFIID) whereby a TAF1 isoform, presumably TAF1-2, is recruited to a core subassembly of tTAFs in spermatocyte nucleoli
Title: Nucleolar colocalization of TAF1 and testis-specific TAFs during Drosophila spermatogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: TBP-associated factor 1

Names: CG17603-PA; CG17603-PB; CG17603-PC; CG17603-PD; CG17603-PE; CG17603-PF; TATA-associated factor 250; TBP-associated factor; TBP-associated factor 250; TBP-associated factor 250kD; TFIID 230 kda subunit; Taf1-PA; Taf1-PB; Taf1-PC; Taf1-PD; Taf1-PE; Taf1-PF; cell lethal; suppressor of Ras85D 3-5

NP_001163532.1

EC 2.3.1.48

EC 2.3.2.23

EC 2.7.11.1

EC 6.2.1.45

NP_001246952.1

EC 2.3.1.48

EC 2.3.2.23

EC 2.7.11.1

EC 6.2.1.45

NP_001287201.1

EC 2.3.1.48

EC 2.3.2.23

EC 2.7.11.1

EC 6.2.1.45

NP_476956.3

EC 2.3.1.48

EC 2.3.2.23

EC 2.7.11.1

EC 6.2.1.45

NP_996159.1

EC 2.3.1.48

EC 2.3.2.23

EC 2.7.11.1

EC 6.2.1.45

NP_996160.1

EC 2.3.1.48

EC 2.3.2.23

EC 2.7.11.1

EC 6.2.1.45

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

6646889..6656048

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260023.1 → NP_001246952.1 TBP-associated factor 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246952.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K602, Q29R44

Conserved Domains (4) summary

cd05511
Location:1518 → 1629

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:15 → 76

TBP-binding; TATA box-binding protein binding

pfam12157
Location:652 → 1114

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1388 → 1418

zf-CCHC_6; Zinc knuckle
NM_206438.2 → NP_996160.1 TBP-associated factor 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996160.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O97068, P51123, Q7KSX6, Q7KSX7, Q86LF7, Q9TX96

UniProtKB/TrEMBL

Q29R44

Conserved Domains (4) summary

cd05511
Location:1475 → 1586

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:15 → 76

TBP-binding; TATA box-binding protein binding

pfam12157
Location:609 → 1071

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1345 → 1375

zf-CCHC_6; Zinc knuckle
NM_206437.2 → NP_996159.1 TBP-associated factor 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996159.1

Status: REVIEWED

UniProtKB/TrEMBL

Q29R44

Conserved Domains (4) summary

cd05511
Location:1475 → 1586

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:15 → 76

TBP-binding; TATA box-binding protein binding

pfam12157
Location:609 → 1071

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1345 → 1375

zf-CCHC_6; Zinc knuckle
NM_001300272.1 → NP_001287201.1 TBP-associated factor 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287201.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGU9, Q29R44

Conserved Domains (5) summary

cd05511
Location:1475 → 1586

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

PHA03307
Location:79 → 313

PHA03307; transcriptional regulator ICP4; Provisional

pfam09247
Location:8 → 76

TBP-binding; TATA box-binding protein binding

pfam12157
Location:609 → 1072

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1345 → 1375

zf-CCHC_6; Zinc knuckle
NM_001170061.1 → NP_001163532.1 TBP-associated factor 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163532.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ72, Q29R44

Conserved Domains (4) summary

cd05511
Location:1475 → 1586

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:15 → 76

TBP-binding; TATA box-binding protein binding

pfam12157
Location:609 → 1071

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1345 → 1375

zf-CCHC_6; Zinc knuckle
NM_057608.5 → NP_476956.3 TBP-associated factor 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476956.3

Status: REVIEWED

UniProtKB/TrEMBL

Q29R44

Related

FBpp0081184

Conserved Domains (4) summary

cd05511
Location:1475 → 1586

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:15 → 76

TBP-binding; TATA box-binding protein binding

pfam12157
Location:609 → 1071

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1345 → 1375

zf-CCHC_6; Zinc knuckle