Cdk9 Cyclin-dependent kinase 9 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdk9provided by FlyBase
Official Full Name: Cyclin-dependent kinase 9provided by FlyBase
Primary source: FLYBASE:FBgn0019949
Locus tag: Dmel_CG5179
See related: AllianceGenome:FB:FBgn0019949
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cdk9; CDK9; CG5179; Dmel\CG5179; DmP-TEFb; P-TEF; P-TEFb; PTefb
Summary: Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of defense response to virus by host; positive regulation of transcription elongation by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in nucleus and polytene chromosome puff. Part of P-TEFb complex and super elongation complex. Is expressed in organism. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22636063..22637727, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18523568..18525232, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The NELF pausing checkpoint mediates the functional divergence of Cdk9.
Title: The NELF pausing checkpoint mediates the functional divergence of Cdk9.
Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain
Title: Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain.
cdk9 is essential for glia survival in adult Drosophila brain.
Title: Cyclin-dependent kinase 9 is required for the survival of adult Drosophila melanogaster glia.
actin participates in transcription elongation by recruiting Cdk9,a catalytic subunit of P-TEFb, for phosphorylation of the Pol II C-terminal domain, and the actin-Cdk9 interaction promotes chromatin remodeling
Title: G-actin participates in RNA polymerase II-dependent transcription elongation by recruiting positive transcription elongation factor b (P-TEFb).
Cdk9 is required for heat shock gene expression, histone methylation and elongation factor recruitment.
Title: Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment.
Genetic transcription and RNA processing of PTefb kinase is coordinated on heat shock genes.
Title: Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	TAS Traceable Author Statement more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of P-TEFb complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin/CDK positive transcription elongation factor complex	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of super elongation complex	IPI Inferred from Physical Interaction more info	PubMed

Names: CG5179-PA; Cdk9-PA; Cyclin-dependent kinase9 2.7; p43 PITALRE; positive transcription elongation factor b; positive transcription elongation factor b, small subunit

NP_477226.2

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