BubR1 Bub1-related kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BubR1provided by FlyBase
Official Full Name: Bub1-related kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0263855
Locus tag: Dmel_CG7838
See related: AllianceGenome:FB:FBgn0263855
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 31/13; BcDNA:LD23835; bub1; Bub1; BUB1; bubr1; bubR1; BUBR1; CG 7838; CG7838; dBUB1; Dmbub1; DmBUB1; DmBubRI; Dmel\CG7838; l(2)k03113; l(2)k06109; mcl(2)Z1525
Summary: Predicted to enable protein kinase activity. Involved in several processes, including chromosome organization; heterochromatin formation; and regulation of mitotic cell cycle phase transition. Located in cytoplasm and kinetochore. Is expressed in central brain primordium; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 42A5-42A6; 2-55 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (5969099..5974385, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1856604..1861890, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BubR1 controls starvation-induced lipolysis via IMD signaling pathway in Drosophila.
Title: BubR1 controls starvation-induced lipolysis via IMD signaling pathway in Drosophila.
The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance.
Title: The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance.
The authors showed that BubR1-mediated the centromere-associated kinesin motor CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays.
Title: BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules.
The Bub3-BubR1 complex on broken DNA inhibits the APC/C locally via the sequestration of Cdc20.
Title: Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes.
a model in which Polo controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 kinetochore recruitment and sustained SAC function.
Title: Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.
Data show that the Mad2 kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 to kinetochores in Drosophila requires BubR1 but not Mad2.
Title: Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.
Reduced BubR1 or Polo function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.
Title: BubR1- and Polo-coated DNA tethers facilitate poleward segregation of acentric chromatids.
BubR1's role in mitosis is discussed.
Title: Separating the spindle, checkpoint, and timer functions of BubR1.
Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20-APC function, preventing the metaphase-to-anaphase transition.
Title: Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint.
essential for sister-chromatid cohesion during meiotic progression in both sexes and for normal maintenance of synaptonemal complex in females
Title: Drosophila BubR1 is essential for meiotic sister-chromatid cohesion and maintenance of synaptonemal complex.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiosis sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid cohesion, centromeric	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of exit from mitosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic sister chromatid separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Bub1-related kinase

Names: BubR1-PA; CG7838-PA; bub related one

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

5969099..5974385 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058034.4 → NP_477382.1 Bub1-related kinase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477382.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z6I7, Q7KN56

Related

FBpp0085368

Conserved Domains (2) summary

cd13981
Location:1174 → 1458

STKc_Bub1_BubR1; Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1

pfam08311
Location:38 → 159

Mad3_BUB1_I; Mad3/BUB1 homology region 1