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    jhamt juvenile hormone acid methyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34977, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jhamtprovided by FlyBase
    Official Full Name
    juvenile hormone acid methyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028841
    Locus tag
    Dmel_CG17330
    See related
    AllianceGenome:FB:FBgn0028841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS09218.5; CG17330; Dmel\CG17330; DmJHAMT; JAHMT; Jhamt; JHamt; JHAMT
    Summary
    Enables farnesoic acid O-methyltransferase activity. Involved in juvenile hormone biosynthetic process and male courtship behavior. Predicted to be active in mitochondrion. Is expressed in several structures, including corpus allatum; embryonic somatic muscle cell; larval brain; and ring gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jhamt in Genome Data Viewer
    Location:
    35F12-35F12; 2-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16365903..16367039)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16365903..16367039)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene calcium-binding protein 1 Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 1 Neighboring gene Imaginal disc growth factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. Bendena WG, et al. Gen Comp Endocrinol, 2011 May 15. PMID 21354154
    2. Juvenile Hormone Is Required in Adult Males for Drosophila Courtship. Wijesekera TP, et al. PLoS One, 2016. PMID 27003411, Free PMC Article
    3. Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme. Sherkhanov S, et al. Sci Rep, 2016 Apr 7. PMID 27053100, Free PMC Article
    4. Photosynthetic production of biodiesel in Synechocystis sp. PCC6803 transformed with insect or plant fatty acid methyltransferase. Kang MJ, et al. Bioprocess Biosyst Eng, 2021 Jul. PMID 33656615
    5. Juvenile hormone synthesis: "esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase. Defelipe LA, et al. Insect Biochem Mol Biol, 2011 Apr. PMID 21195763, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of function of the miRNA bantam in the fly Drosophila melanogaster increased JHAMT expression, while overexpression of the bantam repressed JHAMT expression and resulted in pupal lethality. In addition, there was a conserved set of miRNAs that interacted with JHAMT, and the sesquiterpenoid receptor methoprene-tolerant (Met).
      Title: MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods.
    2. Data show that juvenile hormone acid O-methyltransferase (DmJHAMT) methylates a broad spectrum of fatty acids.
      Title: Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme.
    3. conclude that glutamate promotes dpp expression in corpus allatum, which stimulates juvenile hormone biosynthesis through Tkv and Mad by upregulating JH acid methyltransferase transcription at early larval stages to prevent premature metamorphosis
      Title: DPP-mediated TGFbeta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase.
    4. JHAMT is predominantly expressed in corpora allata, and its developmental expression profile correlates with changes in the juvenile hormone titer.
      Title: Juvenile hormone acid O-methyltransferase in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables farnesoic acid O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in juvenile hormone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in juvenile hormone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    juvenile hormone acid methyltransferase
    Names
    CG17330-PA
    CG17330-PB
    jhamt-PA
    jhamt-PB
    juvenile hormone acid O-Methyl transferase
    juvenile hormone acid O-Methyltransferase
    juvenile hormone acid methyl transferase
    NP_001285980.1
    NP_609793.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16365903..16367039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299051.1 → NP_001285980.1  juvenile hormone acid methyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q767F0, Q8T900, Q9VJK8
      Conserved Domains (2) summary
      COG0500
      Location:6 → 230
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:40 → 137
      Methyltransf_12; Methyltransferase domain

    2. NM_135949.3 → NP_609793.2  juvenile hormone acid methyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609793.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q767F0, Q8T900, Q9VJK8
      Related
      FBpp0099678
      Conserved Domains (2) summary
      COG0500
      Location:6 → 230
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:40 → 137
      Methyltransf_12; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJK8.2 Q9VJK8

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