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    l(2)34Fc lethal (2) 34Fc [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)34Fcprovided by FlyBase
    Official Full Name
    lethal (2) 34Fcprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261534
    Locus tag
    Dmel_CG7532
    See related
    AllianceGenome:FB:FBgn0261534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A2; anon-EST:ParkEST060; BcDNA:RE60882; BG:DS01068.5; br8; CG7532; Dmel\CG7532; DS01068.5; l(2)br8; l34Fc
    Summary
    Involved in defense response to protozoan and negative regulation of immune response. Predicted to be located in extracellular region. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human REELD1 (reeler domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)34Fc in Genome Data Viewer
    Location:
    35A4-35A4; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14349020..14351513, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14349020..14351513, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Spermathecal endopeptidase 2 Neighboring gene mitochondrial transcription termination factor Neighboring gene antisense RNA:CR44850 Neighboring gene uncharacterized protein Neighboring gene lethal (2) 34Fd Neighboring gene long non-coding RNA:CR44851 Neighboring gene Rab14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body. Zhu Y, et al. Insect Biochem Mol Biol, 2003 May. PMID 12706633
    2. A selective screen to recover chromosomal deletions and duplications in Drosophila melanogaster. Gubb D, et al. Genetics, 1988 Jun. PMID 3135239, Free PMC Article
    3. The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation. Ashburner M, et al. Genetics, 1982 Nov. PMID 6816673, Free PMC Article
    4. Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster. O'Donnell J, et al. Genetics, 1977 Jul. PMID 408228, Free PMC Article
    5. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Gubb D, et al. Genetics, 1990 Sep. PMID 2121594, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 34Fc
    Names
    CG7532-PA
    CG7532-PB
    l(2)34Fc-PA
    l(2)34Fc-PB
    lethal 8 in the black-reduced region
    lethal group A2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14349020..14351513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299001.1 → NP_001285930.1  lethal (2) 34Fc, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3Y3
      UniProtKB/TrEMBL
      X2J8E8
      Conserved Domains (1) summary
      pfam02014
      Location:27 → 149
      Reeler; Reeler domain

    2. NM_135866.4 → NP_609710.1  lethal (2) 34Fc, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3Y3
      UniProtKB/TrEMBL
      X2J8E8
      Related
      FBpp0080212
      Conserved Domains (1) summary
      pfam02014
      Location:27 → 149
      Reeler; Reeler domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3Y3.1 Q9V3Y3
    X2J8E8 X2J8E8

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