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    stx stuxnet [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stxprovided by FlyBase
    Official Full Name
    stuxnetprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052676
    Locus tag
    Dmel_CG32676
    See related
    AllianceGenome:FB:FBgn0052676
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32676; CG9725; CG9732; Dmel\CG32676
    Summary
    Involved in proteasomal ubiquitin-independent protein catabolic process. Located in nucleus. Is expressed in adult brain cell body rind. Orthologous to human MIDN (midnolin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stx in Genome Data Viewer
    Location:
    9E1-9E2; 1-32 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10711163..10744943, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10605196..10638976, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene X11Lbeta Neighboring gene Rab at 9E Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44766 Neighboring gene raspberry Neighboring gene Rabphilin Neighboring gene Transport and Golgi organization 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet-Polycomb-Octβ2R cascade. Zhao Z, et al. EMBO Rep, 2021 Feb 3. PMID 33410264, Free PMC Article
    2. Stuxnet fine-tunes Notch dose during development using a functional Polycomb response element. He T, et al. Development, 2023 Jun 1. PMID 37260148
    3. Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila. Ukita Y, et al. Genes Cells, 2022 Jun. PMID 35438236, Free PMC Article
    4. BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites. Emberly E, et al. PLoS Biol, 2008 Dec 23. PMID 19108610, Free PMC Article
    5. Stuxnet Facilitates the Degradation of Polycomb Protein during Development. Du J, et al. Dev Cell, 2016 Jun 20. PMID 27326929, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet-Polycomb-Octbeta2R cascade.
      Title: Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet-Polycomb-Octβ2R cascade.
    2. Stx facilitates Pc degradation in the proteasome, independent of ubiquitin modification.
      Title: Stuxnet Facilitates the Degradation of Polycomb Protein during Development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stuxnet
    Names
    CG32676-PA
    CG32676-PB
    stx-PA
    stx-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10711163..10744943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272497.2 → NP_001259426.1  stuxnet, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXD4, Q9W2R7
      Conserved Domains (1) summary
      cl00155
      Location:66 → 145
      UBQ; Ubiquitin-like proteins

    2. NM_132420.4 → NP_572648.1  stuxnet, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572648.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXD4, Q9W2R7
      Related
      FBpp0071432
      Conserved Domains (1) summary
      cl00155
      Location:66 → 145
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXD4.1 Q8SXD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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