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    mus101 mutagen-sensitive 101 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mus101provided by FlyBase
    Official Full Name
    mutagen-sensitive 101provided by FlyBase
    Primary source
    FLYBASE:FBgn0002878
    Locus tag
    Dmel_CG11156
    See related
    AllianceGenome:FB:FBgn0002878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0148202.1; CG11156; Dmel\CG11156; DmMus101; fs(1)K451; mus 101; mus(1)101; mus-101; Mus101; MUS101; TopBP1; TOPBP1
    Summary
    Involved in mitotic DNA replication checkpoint signaling. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mus101 in Genome Data Viewer
    Location:
    12B4-12B4; 1-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13722246..13727113)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13616279..13621146)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NAD synthetase Neighboring gene Nna1 carboxypeptidase Neighboring gene Mahogunin ring finger 1 Neighboring gene garnet Neighboring gene Gamma-tubulin ring protein 91 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutagen-sensitive mutants in Drosophila melanogaster: effects on premutational damage. Graf U, et al. Mutat Res, 1979 Nov. PMID 118370
    2. A gene controlling condensation of heterochromatin in Drosophila melanogaster. Gatti M, et al. Science, 1983 Jul 1. PMID 6407113
    3. Genetic study on the effects of the repair-deficient mutant females mei-9a, mei-41D5, mus101D1, mus104D1 and mus302D1 of Drosophila on spontaneous and X-ray-induced chromosome loss in the paternal genome. Cooper SF, et al. Mutat Res, 1981 May. PMID 6795496
    4. The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. Chen YT, et al. J Biol Chem, 2016 Jun 17. PMID 27129233, Free PMC Article
    5. Characterization of postreplication repair in mutagen-sensitive strains of Drosophila melanogaster. Boyd JB, et al. Genetics, 1976 Nov. PMID 826451, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila mus101 is also involved in chorion gene amplification, mostly functioning in initiation, rather than elongation.
      Title: Initiation of Drosophila chorion gene amplification requires Claspin and mus101, whereas Claspin, but not mus101, plays a major role during elongation.
    2. The Top2-Mus101 interaction is important for maintaining the fidelity of chromosome segregation during mitosis.
      Title: The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mutagen-sensitive 101
    Names
    CG11156-PA
    mus101-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13722246..13727113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080170.4 → NP_524909.1  mutagen-sensitive 101 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU37, Q9VY97
      Related
      FBpp0073648
      Conserved Domains (2) summary
      cd00027
      Location:1210 → 1279
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00533
      Location:707 → 778
      BRCT; BRCA1 C Terminus (BRCT) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XXV4 Q2XXV4
    Q7YU37 Q7YU37
    Q9GTU6 Q9GTU6
    Q9VY97 Q9VY97

    Gene LinkOut

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