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    CG4301 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32610, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4301provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030747
    Locus tag
    Dmel_CG4301
    See related
    AllianceGenome:FB:FBgn0030747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DmCG4301; Dmel\CG4301
    Summary
    Predicted to enable flippase activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia; autosomal dominant nonsyndromic deafness; and hypomyelinating leukodystrophy 24. Orthologous to human ATP11A (ATPase phospholipid transporting 11A); ATP11B (ATPase phospholipid transporting 11B (putative)); and ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4301 in Genome Data Viewer
    Location:
    14C4-14C4; 1-53 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16405509..16414651)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16299542..16308684)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene TH1 Neighboring gene meiotic 41 Neighboring gene uncharacterized protein Neighboring gene TNF-receptor-associated factor-like Neighboring gene Annexin B11 Neighboring gene hangover

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functions of phospholipid flippases. Tanaka K, et al. J Biochem, 2011 Feb. PMID 21134888
    2. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250
    3. P-type ATPases in Caenorhabditis and Drosophila: implications for evolution of the P-type ATPase subunit families with special reference to the Na,K-ATPase and H,K-ATPase subgroup. Okamura H, et al. J Membr Biol, 2003 Jan 1. PMID 12532273
    4. Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Ma Z, et al. Genetics, 2012 Apr. PMID 22234859, Free PMC Article
    5. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables flippase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of phospholipid-translocating ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4301-PA
    CG4301-PB
    CG4301-PC
    NP_001245711.1
    NP_001245712.1
    NP_573125.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16405509..16414651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258783.2 → NP_001245712.1  uncharacterized protein Dmel_CG4301, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KKD0, M9NEK4
      Conserved Domains (5) summary
      pfam00122
      Location:84 → 302
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:713 → 802
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:14 → 78
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1047 → 1296
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1015 → 1045
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001258782.2 → NP_001245711.1  uncharacterized protein Dmel_CG4301, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KKD0, M9NGI1
      Conserved Domains (5) summary
      pfam00122
      Location:95 → 313
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:724 → 813
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:25 → 89
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1058 → 1307
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1026 → 1056
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. NM_132897.3 → NP_573125.1  uncharacterized protein Dmel_CG4301, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KKD0, Q9VXG6
      Related
      FBpp0074048
      Conserved Domains (6) summary
      TIGR01652
      Location:74 → 1317
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:127 → 345
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:734 → 823
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:57 → 121
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1068 → 1317
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1036 → 1066
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEK4 M9NEK4
    M9NGI1 M9NGI1
    Q8MZ40 Q8MZ40
    Q9VXG6 Q9VXG6

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