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    Spn28F Serpin 28F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn28Fprovided by FlyBase
    Official Full Name
    Serpin 28Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028987
    Locus tag
    Dmel_CG8137
    See related
    AllianceGenome:FB:FBgn0028987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8137; Dmel\CG8137; sp2; Sp2; spn2; Spn2
    Summary
    Predicted to enable hormone binding activity and serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; adult hemolymph; female reproductive system; ovary; and sperm storage organ. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB12 (serpin family B member 12); and SERPINB13 (serpin family B member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn28F in Genome Data Viewer
    Location:
    28F5-28F5; 2-30 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8240414..8241800, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8240414..8241800, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Sorting nexin 6 Neighboring gene PDGF- and VEGF-receptor related Neighboring gene long non-coding RNA:CR43262 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α. Sepulveda D, et al. Mol Cell, 2018 Jan 18. PMID 29351844
    2. A novel Drosophila serpin that inhibits serine proteases. Han J, et al. FEBS Lett, 2000 Feb 25. PMID 10692585
    3. DEHP toxicity on vision, neuromuscular junction, and courtship behaviors of Drosophila. Chen MY, et al. Environ Pollut, 2018 Dec. PMID 30293038
    4. Targeted gene deletion and phenotypic analysis of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F. Mueller JL, et al. Genetics, 2008 Mar. PMID 18245332, Free PMC Article
    5. Serpins in arthropod biology. Meekins DA, et al. Semin Cell Dev Biol, 2017 Feb. PMID 27603121, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 28F
    Names
    CG8137-PA
    Spn28F-PA
    serine protease inhibitor 2
    serpin 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8240414..8241800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080218.5 → NP_524957.2  serpin 28F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524957.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLL8, Q9VLQ7
      Related
      FBpp0079243
      Conserved Domains (1) summary
      cd00172
      Location:14 → 370
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSJ4 Q8MSJ4
    Q9U1I7 Q9U1I7
    Q9VLQ7 Q9VLQ7

    Gene LinkOut

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