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    hrm hermes [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrmprovided by FlyBase
    Official Full Name
    hermesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033028
    Locus tag
    Dmel_CG11665
    See related
    AllianceGenome:FB:FBgn0033028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11665; Dmel\CG11665; Hermes
    Summary
    Enables pyruvate secondary active transmembrane transporter activity. Involved in plasma membrane pyruvate transport. Located in plasma membrane. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hrm in Genome Data Viewer
    Location:
    41F6-41F6; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5640915..5652815, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1528420..1540320, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Fission, mitochondrial 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45472 Neighboring gene CCR4-NOT transcription complex subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. Xu D, et al. PLoS Genet, 2023 Sep. PMID 37733679, Free PMC Article
    2. Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila. Rabah Y, et al. Nat Metab, 2023 Nov. PMID 37932430, Free PMC Article
    3. dMyc-dependent upregulation of CD98 amino acid transporters is required for Drosophila brain tumor growth. Rebelo AR, et al. Cell Mol Life Sci, 2023 Jan 6. PMID 36609617, Free PMC Article
    4. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu Y, et al. Nat Commun, 2016 Feb 1. PMID 26833246, Free PMC Article
    5. dTrmt10A impacts Hsp70 chaperone m(6)A levels and the stress response in the Drosophila brain. Perlegos AE, et al. Sci Rep, 2023 Dec 28. PMID 38155219, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5644537-5644489 mobile_element_type = transposon:INE-1{}5059
    • Loc: c5645255-5645046 mobile_element_type = transposon:INE-1{}5061
    • Loc: c5646356-5646156 mobile_element_type = transposon:INE-1{}5062
    • Loc: c5649611-5649558 mobile_element_type = transposon:INE-1{}5068
    • Loc: c5649719-5649632 mobile_element_type = transposon:INE-1{}5072
    • Loc: c5650444-5650112 mobile_element_type = transposon:HB{}5693
    • Loc: c5650571-5650446 mobile_element_type = transposon:INE-1{}3428

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in plasma membrane lactate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma membrane pyruvate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hermes
    Names
    CG11665-PA
    CG11665-PB
    hrm-PA
    hrm-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5640915..5652815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299212.1 → NP_001286141.1  hermes, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286141.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWI7
      Conserved Domains (2) summary
      cd06174
      Location:59 → 234
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:49 → 653
      2A0113; monocarboxylate transporter 1

    2. NM_136330.2 → NP_610174.1  hermes, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWI7
      Related
      FBpp0085408
      Conserved Domains (2) summary
      cd06174
      Location:59 → 234
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:49 → 653
      2A0113; monocarboxylate transporter 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWI7 Q7JWI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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